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Occurrence of pharmacologically active benzodiazepines in trace amounts in wheat and potato.
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Aqueous acid extracts of wheat grains and of potato tuber were found to contain a series of compounds displaying a high affinity to the central type benzodiazepine receptor (BZR) in mammalian brain. Further analysis using different HPLC systems, as well as mass spectrometry and gas chromatography
Increase of natural benzodiazepines in wheat and potato during germination.
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Aqueous acid extracts of wheat grains and potato exhibit after HPLC separation a series of compounds that are able to inhibit the binding of benzodiazepines to benzodiazepine receptors of rat brain membranes. In wheat one of the inhibiting compounds was shown to be identical to diazepam by means of
Potato (Solanum tuberosum) juice exerts an anticonvulsant effect in mice through binding to GABA receptors.
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Naturally occurring benzodiazepines have been identified in regular food such as wheat and potato, but there is still no evidence that potato extracts can affect CNS responses in vivo. Here we found that undiluted potato juice and potato juice diluted with saline 1 : 2 administered 10 min
Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm ('African potato') aqueous extract in mice.
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Extracts of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm (popularly known as 'African potato') are extensively used in South African traditional medicines for the treatment, management and/or control of an array of human ailments, including childhood convulsions and epilepsy. This
Identification of benzodiazepines in Artemisia dracunculus and Solanum tuberosum rationalizing their endogenous formation in plant tissue.
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Sterile cultivated plant cell tissues and cell regenerates of several species were tested for their binding affinity to the central human benzodiazepine receptor. Binding activity was found in extracts of Artemisia dracunculus cell tissue (IC(50) = 7 microg/ml) and, to a lesser extent, in plant
Heterocycles as physiological ligands for the benzodiazepine receptor and for other binding sites.
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Recently pharmacologically active benzodiazepines, including diazepam, have been identified in common foodstuffs, e.g. wheat and potato. The chronical intake by way of plant food may explain the existence of benzodiazepines in the brain and in other tissues of various mammalians and man. Hitherto
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