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Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration.
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Synthetic fragrances are persistent environmental pollutants that tend to bioaccumulate in animal tissues. They are widely used in personal care products and cleaning agents. Worldwide production of Galaxolide and Tonalide are in excess of 4500 tons annually. Because of their widespread production
Axonal degeneration and neuropathy target esterase.
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This brief review summarizes recent observations which suggest a possible mechanism for organophosphate-induced delayed neuropathy (OPIDN). Neuropathy target esterase (NTE) has been shown to deacylate endoplasmic reticulum (ER) membrane phosphatidylcholine (PtdCho). Raised levels of PtdCho are
Localization of non-specific esterase and acid phosphatase in human fibroblast from skeletal muscle atrophy.
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The intracellular localization of non-specific esterase and acid phosphatase was investigated in human fibroblast cells from skeletal muscle atrophy. Non-specific esterase and acid phosphatase positive sites were visualized ultrastructurally in the fibroblast. Electron microscopy for the
On the effect of motor nerve degeneration on the fine-structural localization of esterases in the mammalian motor end-plate.
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On the changes in ali-esterase and pseudocholinesterase activity of chicken sciatic nerve during Wallerian degeneration and their correlation with cellular proliferation.
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[Effects of ethylendiamine tetraacetic acid on choline esterase in rat liver in normal state and experimental fatty degeneration].
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Cholinesterases and eserine-resistant carboxylic esterases in degenerating and regenerating motor end plates of the rat.
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Cholesterol esters and hydrolytic cholesterol esterase during Wallerian degeneration.
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Cloning and sequence analysis of cDNA encoding a putative juvenile hormone esterase from the Colorado potato beetle.
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In the Colorado potato beetle, Leptinotarsa decemlineata, reproduction and diapause are mediated by the juvenile hormone (JH) titer in the hemolymph. This titer is controlled by JH synthesis in the corpora allata and by JH degradation. The main pathway of JH degradation is by JH esterase in the
Ocular myasthenia gravis associated with x-linked recessive spinal and bulbar muscular atrophy.
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We describe a 34-year-old patient who was admitted with episodic diplopia, ptosis, and swallowing difficulties of 6 months duration. He also had some muscle cramps aggravated by exercise since the age of 20. Bilateral ptosis of the eyelids, normal gaze, rare fasciculations of the tongue, easy
8-[2-(2-Pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid and its diastereomers improve age-related cognitive deterioration.
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Racemic 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a linoleic acid derivative with cyclopropane rings instead of cis-double bonds, contains possible four diastereomers such as α,α-, α,β-, β,α-, and β,β-DCP-LA. The present study examined the effect of racemic and
Determination of hair cell degeneration and hair cell death in neomycin treated cultures of the neonatal rat cochlea.
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The spatial-temporal course of hair cell degeneration and hair cell death was examined in the mammalian cochlea following aminoglycoside treatment. Organotypic cultures were established from postnatal rats (P3) and treated with 1 mM neomycin sulfate for 12-48 h and analyzed using a live/dead assay
Acetylcholine esterase inhibitor donepezil improves dynamic cerebrovascular regulation in Alzheimer patients.
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BACKGROUND
Alzheimer's disease (AD) leads to a degeneration of the nucleus basalis of Meynert and thus to decreased cholinergic tonus in the brain. The transcription of endothelial nitric oxide synthase depends on an adequate cholinergic innervation of microvessels and vasoregulative abnormalities
Effects of androgen and antiandrogen treatment on canine prostatic arginine esterase.
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A series of experiments were conducted to investigate the regulation of the primary secretory protein of the canine prostate, arginine esterase, by androgens and/or new antiandrogen under development. In the first experiment, castration decreased (P less than 0.05) prostatic arginine esterase levels
Purification and characterization of neuropathy target esterase (NTE) from rat brain.
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Neuropathy target esterase (NTE) is an integral membrane protein in vertebrate neurons and a member of a novel family of putative serine hydrolases. Neuropathic organophosphates react covalently with the active site serine residue of NTE, causing degeneration of long axons in spinal cord and
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