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eucalyptus gunnii/antidepresan
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Behavioral characterization of CD26 deficient mice in animal tests of anxiety and antidepressant-like activity.
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CD26 exhibits a dipeptidylpeptidase-IV function (DPPIV) which regulates neuropeptide activity by N-terminal processing. Because abnormal plasma DPPIV was associated in mammals with behavioral changes, we examined the behavior of CD26-/- mice resulting from targeted inactivation of the gene. These
A schematic representation of the psychopharmacological profile of antidepressants.
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1. Using simple animal tests, "behavioural" and "biochemical" aspects of depression, anxiolysis, disinhibition, psychostimulation and sedation were investigated in mice using a variety of antidepressant drugs. 2. Dothiepin and mianserin (16 and 32 mg/kg), fluoxetine (32 and 64 mg/kg), maprotiline
Taurine trials in animal models offer no support for anxiolytic, antidepressant or stimulant effects.
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BACKGROUND
Taurine is a conditionally-essential amino acid that is found in high concentrations in the CNS and is essential for growth and survival of neurons. Taurine had been clinically tested in a number of diseases with variable results. In the context of neuropsychiatry, taurine was found to be
Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities.
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OBJECTIVE
The pharmacological profile of escitalopram, the S-(+)-enantiomer of citalopram, was studied and compared with citalopram and the R-(-)-enantiomer, R-citalopram.
METHODS
Inhibition of the serotonin transporter (5-HTT) was studied in COS-1 cells expressing the human 5-HTT (h-5-HTT) and in
Investigation of the Anxiolytic and Antidepressant Effects of Eucalyptol (1,8-Cineole), a Compound From Eucalyptus, in the Adult Male Sprague-Dawley Rat.
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Anxiety and depression are debilitating, costly psychological disorders that account for $133 billion in direct medical expenses per year in the United States. Finding alternative means of treatment to reduce the personal and financial burden for patients with these disorders, while maintaining
GLP-1 is both anxiogenic and antidepressant; divergent effects of acute and chronic GLP-1 on emotionality.
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Glucagon-like peptide 1 (GLP-1), produced in the intestine and hindbrain, is known for its glucoregulatory and appetite suppressing effects. GLP-1 agonists are in clinical use for treatment of type 2 diabetes and obesity. GLP-1, however, may also affect brain areas associated with emotionality
Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?
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The behavioral profiles of five clinically used selective serotonin reuptake inhibitors (SSRIs) citalopram, paroxetine, sertraline, fluvoxamine and fluoxetine, have been compared in animal models of antidepressant (mouse forced swim test), anxiolytic (exploration of black and white test box and
Possible Reversible Cerebral Vasoconstriction Syndrome Associated with Eucalyptus: Case Report.
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UNASSIGNED
Reversible cerebral vasoconstrictive syndrome (RCVS) has characteristic clinical features, brain imaging and Angiographic features. The majority of RCVS cases are associated with the use of antidepressants, polysubstance abuse, and nasal decongestants. We here present a case that
Anxiolytic profile of ropinirole in the rat, mouse and common marmoset.
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BACKGROUND
Some features of Parkinson's disease are exacerbated by stress and anxiety and it is important to understand the effects of dopamine receptor agonists on measures of anxiety. The aim of this study was to assess the effects of the dopamine D2/D3 receptor agonist ropinirole in models of
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