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[Day time fatigue in frontal lobe epilepsy with primarily sleep-related seizures. A case report].
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We present a 43-year-old patient who has had up to 15 frontal lobe seizures nightly for 12 years. The patient had no complaints apart from excessive daytime sleepiness. Neurological and psychiatric examination as well as cerebral computed tomograph and magnetic resonance imaging were normal. After
Efficacy and safety of perampanel in generalized and focal to bilateral tonic-clonic seizures: A comparative study of Asian and non-Asian populations.
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Perampanel is an approved adjunctive treatment for focal seizures with or without focal to bilateral tonic-clonic (FBTC) seizures and generalized tonic-clonic (GTC) seizures. We compared efficacy and safety of perampanel vs placebo in Asian and non-Asian populations in a post hoc analysis of pooled
The cognitive effects of oxcarbazepine versus carbamazepine or valproate in newly diagnosed children with partial seizures.
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OBJECTIVE
To investigate the effect of oxcarbazepine against standard antiepileptic drug therapy (carbamazepine and valproate) on cognitive function in children and adolescents (aged 6 to <17 years) with newly diagnosed partial seizures.
METHODS
A multicentre, open-label, randomised, active-control,
Perampanel in the management of partial-onset seizures: a review of safety, efficacy, and patient acceptability.
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Perampanel (PER) is a novel antiepileptic drug recently introduced for the adjunctive treatment in epilepsy patients aged 12 years or older with partial-onset seizures with or without secondary generalization in the US and Europe. Its antiepileptic action is based on noncompetitive inhibition of
Postictal symptoms help distinguish patients with epileptic seizures from those with non-epileptic seizures.
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The aim of the study was to assess whether post-ictal symptoms can help distinguish patients who have epileptic seizures from those with non-epileptic seizures (NES). We reviewed the spontaneous responses to the question 'What symptoms do you have after a seizure?' in 16 patients with epileptic
Ezogabine: a novel antiepileptic as adjunctive therapy for partial onset seizures.
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Ezogabine (retigabine) is a novel antiepileptic agent which primarily acts to stabilize neuronal potassium-gated ion channels. Currently no other marketed antiepileptic drugs (AEDs) share this mode of action. Ezogabine's pharmacokinetic profile is characterized by rapid absorption and linear,
Seizure activity following atracurium continuous rate infusion in three mechanically ventilated juvenile dogs
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Objective: To describe patient recovery in dogs that had undergone mechanical ventilation (MV) and received atracurium as a continuous rate infusion (CRI).
Case series summary:
Lacosamide: an adjunctive agent for partial-onset seizures and potential therapy for neuropathic pain.
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OBJECTIVE
To review the pharmacology, pharmacokinetics, efficacy, and safety of lacosamide, a new agent for use as adjunctive treatment in partial-onset seizures and a potential agent for treatment of neuropathic pain.
METHODS
A MEDLINE search (1966-July 2009) was conducted using the key words
A method for deciding about the possible safety of modafinil and armodafinil in patients with seizure disorder.
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Modafinil or armodafinil (ar/mod) may be considered for patients with approved or unapproved indications, including excessive daytime drowsiness, fatigue, attention-deficit/hyperactivity disorder (ADHD), or addictions. Ar/mod is classified as a psychostimulant, and psychostimulants have been
[The effect of dipropyl acetic acid (Convules) in epileptic adults with a high frequency of seizures].
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The anti-convulsive action of dipropyl acetic acid (Convulex) was tested in 21 patients with grandmal seizures (GM) and/or temporal lobe attacks (TL), or with Jacksonian epilepsy. Patients were chosen according to a negative selection system. Results showed that in GM and TL seizures, Convulex
Lamotrigine add-on therapy for drug-resistant generalised tonic-clonic seizures
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Background: This is an update of the Cochrane Review first published in 2010; it includes one additional study. Primary generalised tonic-clonic seizures are a type of generalised seizure. Other types of seizures include: absence,
Gabapentin in generalized seizures.
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The efficacy of gabapentin (Neurontin), in generalized seizures was evaluated in this 14 week, double-blind, placebo-controlled, parallel-group, add-on, multicenter study. A total of 129 patients with refractory generalized seizures were randomized to receive either placebo or 1200 mg/day gabapentin
Clinical efficacy of perampanel for partial-onset and primary generalized tonic-clonic seizures.
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OBJECTIVE
Perampanel, a selective noncompetitive antagonist at the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, is highly effective in a wide range of experimental models. Although initially licensed as adjunctive therapy for partial seizures with or without secondary
A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures. Topiramate YTC Study Group.
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OBJECTIVE
Topiramate is effective as adjunctive treatment of partial-onset seizures in adults. The efficacy and safety of topiramate as adjunctive therapy for the treatment of primary generalized tonic-clonic (PGTC) seizures were investigated in a randomized, double-blind, placebo-controlled
Dose-Response Study of Vigabatrin as add-on therapy in patients with uncontrolled complex partial seizures.
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OBJECTIVE
This placebo-controlled, randomized, double-blind, multicenter study examined the efficacy and safety of three daily doses of vigabatrin (VGB; 1, 3, or 6 g) as add-on therapy in 174 patients with previously uncontrolled complex partial seizures with or without secondary
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