White bread consumption on the study visit

Blood Pressure

further fasting

white bread consumption

mango consumption

Regal Human Nutrition Research Center

The Acute Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose

Changes in measures of blood pressure (mmHg) from baseline to two hours following fasting or consumption of white bread or mango.

Changes in blood glucose from baseline to two hours following fasting or consumption of white bread or mango.

Changes in insulin from baseline to two hours following fasting or consumption of white bread or mango.

University of California, Davis

National Mango Board

USDA Beltsville Human Nutrition Research Center

Watercress will be tested in its natural form as a food item that will supplement the usual diet, via the prescription of watercress as whole food added daily to the usual diet. The intervention group will be asked to consume 100 grams of watercress per day, in addition to their usual diet for the total time of RT treatment. These 100 grams of watercress per day will allow the achievement of the daily "therapeutic" dose.

The control group will receive the standard of care, thus will maintain their ad libitum diet.

Long-term Effects Secondary to Cancer Therapy in Adults

100g of watercress daily during radiation therapy

Watercress

Hospital de Santa Maria

Does Watercress Intake Have an Impact on Cancer Patients Outcomes: a Longitudinal Trial

Does Watercress Intake Have an Impact on Cancer Patients Outcomes: a Randomized Longitudinal Trial

as an indirect measure of cell membrane integrity, function and metabolism

assessed by tetrapolar multifrequency Bioimpedance Analysis (BIA) and CT scan images; CT scans analysis will be performed in collaboration with expert groups

Assessed by the RTOG Common Toxicity Criteria, developed by the Eastern Cooperative Oncology Group (RTOG)

Evaluated by a radiation oncologist, using a validated toxicity scale

will be assessed by the European Organisation for Research and Treatment of Cancer (EORTC-QLQ C30), validated for Oncology

DNA damage assessment by Comet assay in lymphocytes has been used extensively as a surrogate biomarker to measure exposure to genotoxic agents and assess cancer risk in human studies by us and others. biological samples will comprise serum or plasma (1 mL) prepared from blood samples collected in Heparin tubes and urine (1 mL). Metabolomic profiles will be measured on a 700 MHz 1H NMR spectrometer equipped with a cryo-probe for enhanced sensitivity. 1H NMR spectroscopy: high throughput metabolic phenotyping is a powerful approach for characterising biochemical signatures of biological samples. We will couple high-resolution 1H NMR spectroscopy and mathematical modelling approaches to determine the metabolic profile in biological samples from patients.

Metabolomics simultaneously measures thousands of low molecular weight metabolites providing holistic information on the biochemical status of the body. Previous metabolomic studies have identified cancer-associated perturbations in the metabolic phenotypes of patients. This study will explore the ability of watercress to improve the restorative effects of radiotherapy in breast cancer patients on the metabolic status towards a healthy phenotype

assessed by the method Patient-Generated Subjective Global Assessment, specific and validated for Oncology

Will derive from a diet history and a 24-hour-recall food questionnaire. The software Dietplan6 (Forestfield Software Ltd 2013®, Horsham, UK) will analyze the nutrient content of foods consumed

The plasma samples analysis will also include the measurement of carotenoids and flavonoids, which are present in watercress, and are related with antigenotoxic effects in vitro and have anti-proliferative effects, as demonstrated in several studies. Urine samples analysis will allow the measurement of flavonoids.

assessed by tetrapolar multifrequency Bioimpedance Analysis (BIA)

Paula Ravasco

Principal Investigator

University of Lisbon

Dental Plaque

Gingivitis

The subjects were instructed to brush their teeth as usual and to rinse with the 10mL of Mouthwash contain 5% Green Propolis, twice a day, for one minute, right after their meals in the morning and at night. The treatment was performed during three months

green propolis mouthwash

to promote the protection of population health through the sanitary control of production and marketing of products and services subject to sanitary surveillance, including the environments, processes, materials and t

Universidade Federal de Minas Gerais (UFMG)

Preliminary Evidence of the Efficacy of a Mouthwash Containing 5% Propolis for the Control of Plaque and Gingivitis

Clinical Preliminary Evidence of the Efficacy of a Mouthwash Containing 5% Propolis for the Control of Plaque and Gingivitis: Phase II Study

Difference in the Gingival Index scores between the start and the end of the study.

Difference in the Plaque Index scores between the start and the end of the study.

Vagner Rodrigues Santos

Federal University of Minas Gerais

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do estado de Minas Gerais

The control is the wholegrain bread enriched with bran that has not been pretreated.

This is a wholegrain bread enriched with bran that has been pretreated with food-grade enzymes and yeast fermentation

Healthy Males

Ferulic acid is naturally contained in wholegrain bread. Bran is the main source of ferulic acid while is low in white flour. Ferulic acid is mainly covalently bound to fiber and low bioaccessible. The bran is pretreated to increase the bioavailability of ferulic acid by increasing the free ferulic acid released from the food matrix.

ferulic acid

Treated bran bread

The control is the wholegrain bread enriched with bran that has not been pretreated

ferulic acid/kanker

The Acute Effect of Mango Intake (Mangifera Indica L.) on Blood Pressure and Blood Glucose

Does Watercress Intake Have an Impact on Cancer Patients Outcomes: a Longitudinal Trial

Preliminary Evidence of the Efficacy of a Mouthwash Containing 5% Propolis for the Control of Plaque and Gingivitis

Increasing Ferulic Acid Bioavailability in Bran

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