Overweight

Obesity

Subjects in the Med-D group will be assigned a personalized diet prepared on the basis of own eating habits as established by 7-d food diary recalls. Energy values of habitual diets will be kept unchanged during Med-D intervention. Briefly, Med-D will be prepared so as to achieve a weekly consumption of:
7 portions of milk or yogurt plus whole grain cereals,
7 portions of nuts (30g)
At least 3 portion of absolute legumes
14 portions of vegetables
21 portions of fruit
4 portions of whole grain pasta
3 portions of whole grain pasta with vegetables or legumes
7 portions of whole grain bread
3 portions of fish
Extravirgin olive oil as unique source of discretional fats All subjects will be requested not to change physical activity levels during the 8 week intervention period.

Mediterranean diet

Control subjects will not change their habitual diet during intervention. All subjects will be requested not to change physical activity levels during the 8 week intervention period.

Control Diet

Federico II University

Diet-induced Arrangement of the Gut Microbiome for Improvement of Cardiometabolic Health

Measure of plasma concentrations (mg/dL) of Total-, LDL-, and HDL-Cholesterol, as well as Triglycerides

measure of short chain fatty acids from faecal samples

Measure of serum polyphenols concentration (nmol/L)

Measure of plasma GLP-1 concentrations (mg/dL)

Measure of plasma GIP concentrations (mg/dL)

Measure of plasma Glucagon concentrations (mg/dL)

Measure of plasma Ghrelin concentrations (mg/dL)

Measure of plasma Insulin concentrations (mg/dL)

Measure of plasma endocannabinoids concentrations (mg/dL)

Measure of plasma C-reactive protein (mmol/L)

We will decide as soon as we will have data analysis completed and a clear idea on publication rute according with the other coauthors.

Paola Vitaglione

Associate Professor

Diet based in aleurone-enriched products for a period of 8 weeks.

Diet based on refined cereal products for a period of 8 weeks.

Glucose and Lipid Metabolism

Incretin Hormones Plasma Levels

Inflammation, Oxidative Stress and Endothelial Function

Aleurone

Control

Dept. Clinical Medicine and Surgery, Federico II University

Effects of Aleurone-enriched Products on Cardiovascular Risk Factors

Effects of Aleurone-enriched Products on Fasting and Postprandial Glycemic Homeostasis and Lipid Metabolism in High Cardiovascular Risk Subjects

rivellese angela

Gabriele Riccardi

Subjects will consume whole grains every day for two months

Subjects will consume their habitual diet

Subjects will consume whole grains at dose of 80 g/die, for two months

Whole grains

Department of Food Science

Whole Grain Polyphenol Bioavailability and Effects on Health

Whole Grain Polyphenol Bioavailability and Effects on Inflammatory, Oxidative and Hormonal Status

Measure of serum polyphenol concentration (nmol/L)

Measure of plasma FRAP (µmol/L) and MDA (µmol/L) concentrations.

Measure of serum CRP, IL-6, TNF-α, PAI-1, Visfatin, Resistin concentration (pg/mL)

It will be evaluated following a standard meal test. In particular plasma response (pg/mL) of Ghrelin, PYY, Leptin, GIP, GLP-1, PP and insulin will be assessed

ferulic acid/obesitas

Diet-induced Arrangement of the Gut Microbiome for Improvement of Cardiometabolic Health

Effects of Aleurone-enriched Products on Cardiovascular Risk Factors

Whole Grain Polyphenol Bioavailability and Effects on Health

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