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Nortrachelogenin, a major lignan component of Pinus sylvestris knot extract, suppresses IL-4 and IL-13 -induced alternative macrophage activation and partially reverses bleomycin-induced dermal fibrosis.
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Excessive alternative macrophage activation contributes to fibrosis. We studied the effects of nortrachelogenin, the major lignan component of Pinus sylvestris knot extract, on alternative (M2) macrophage activation. J774 murine and THP-1 human macrophages were cultured with IL-4+IL-13 to induce
Pycnogenol prevents peritoneal adhesions.
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OBJECTIVE
This study tested the ability of pycnogenol, an extract from the bark of the French maritime pine (Pinus pinaster), to prevent intra-abdominal adhesions.
METHODS
Thirty female Wistar albino rats were separated randomly into three equal groups: Group (1) the control group, which underwent
Hepatoprotective effects of pycnogenol in a rat model of non-alcoholic steatohepatitis.
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Oxidative stress is considered as a mechanism of hepatocellular injury in non-alcoholic steatohepatitis (NASH). Pycnogenol (PYC) is the natural plant extract from the bark of Pinus pinaster Aiton. and has potent antioxidant activities. We studied the protective effect of PYC on excessive fat
Chromatographic analysis, anti-proliferative and radical scavenging activity of Pinus wallichina essential oil growing in high altitude areas of Kashmir, India.
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OBJECTIVE
To evaluate the in vitro anti-proliferative and radical scavenging properties of the essential oil and its fractions and to determine the chemo-type of P. wallichiana essential oil.
METHODS
Pinus wallichiana oil was extracted by hydro-distillation and fractionated by silica gel column
Inhibitory effects of Pycnogenol® on hepatitis C virus replication.
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Chronic hepatitis C virus (HCV) infection increases the risk of liver cirrhosis and hepatocellular carcinoma. In the last decade, the current standard HCV treatment, pegylated interferon and ribavirin, have limited efficacy and significant side effects. Novel direct acting antivirals show promise,
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