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Phase I and clinical pharmacology study of intravenous flavone acetic acid (NSC 347512).
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We have conducted a Phase I and pharmacological study of flavone acetic acid, one of a series of novel flavonoids. The drug was administered i.v. weekly for 4 weeks, with a 2-week rest and then repeated. Flavone acetic acid was given initially in a 1-h infusion, but at the 3900-mg/m2 dose level, the
[Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers (Endotelon)].
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Light vision is a major element of the visual function. However, it varies from one subject to another. Many factors may modify it in the absence of amy retinal pathology (âge, fatigue, stress). A lower resistance to glare and an alteration of scotopic vision are often mentioned during medical
Identification of the chemical components of Saussurea involucrata by high-resolution mass spectrometry and the mass spectral trees similarity filter technique.
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BACKGROUND
Saussurea involucrata is a rare traditional Chinese medicine (TCM) that displays anti-fatigue, anti-inflammatory and anti-tumor effects. In this paper, the different chemical components of Saussurea involucrata were characterized and identified over a wide dynamic range by
A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer.
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BACKGROUND
Flavopiridol (HMR 1275) is a synthetic flavone with antineoplastic properties through inhibition of cyclin-dependent kinase inhibitor. Flavopiridol synergizes in a sequence-dependent fashion with chemotherapy. Major adverse events of flavopiridol in single agent phase I studies are
Phase II study of flavopiridol in patients with advanced colorectal cancer.
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BACKGROUND
Flavopiridol, a synthetic flavone that inhibits cell cycle progression, has demonstrated activity in colon cancer in xenografts and in a phase I trial. We evaluated flavopiridol in a phase II trial in patients with previously untreated advanced colorectal cancer (ACRC).
METHODS
Twenty
Areca catechu L. (Arecaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology.
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BACKGROUND
Areca catechu L. (Arecaceae), widely distributed in South and Southeast Asia, is a popular traditional herbal medicine that can be chewed for the purpose of dispersing accumulated fluid in the abdominal cavity and killing worms. The present paper aims to provide an up-to-date review on
Efficacy and Tolerability of Phytomedicines in Multiple Sclerosis Patients: A Review.
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Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disorder of the central nervous system (CNS) that can cause cognition, mobility, and sensory impairments. It is considered one of the most common non-traumatic causes of disability in the world. The aim of the present article was to
Brain "fog," inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin.
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Brain "fog" is a constellation of symptoms that include reduced cognition, inability to concentrate and multitask, as well as loss of short and long term memory. Brain "fog" characterizes patients with autism spectrum disorders (ASDs), celiac disease, chronic fatigue syndrome, fibromyalgia,
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