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Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo.
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Tumour hyperthermia, although potentially a powerful therapeutic agent and radiation sensitizer, is hindered by a number of considerations including inhomogeneous heating of deep seated tumours due to energy deposition and perfusion issues. One solution is to design hyperthermia sensitizers to
Quercetin does not alter lipopolysaccharide-induced fever in rats.
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Fever is considered an important component of the acute phase response of the body in defence against invading organisms such as bacteria. Quercetin, an important representative of the flavonoid class, has been extensively studied as an anti-inflammatory agent. In the present study, we investigated
Flavonoids as Multi-target Inhibitors for Proteins Associated with Ebola Virus: In Silico Discovery Using Virtual Screening and Molecular Docking Studies.
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Ebola virus is a single-stranded, negative-sense RNA virus that causes severe hemorrhagic fever in humans and non-human primates. This virus is unreceptive to a large portion of the known antiviral drugs, and there is no valid treatment as on date for disease created by this pathogen. Looking into
Flavonoids as multi-target inhibitors for proteins associated with Ebola virus: in-silico discovery using virtual screening and molecular docking studies.
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Ebola virus is a single-stranded, negative-sense RNA virus that causes severe hemorrhagic fever in humans and nonhuman primates. This virus is unreceptive to a large portion of the known antiviral drugs and there is no valid treatment as on date for disease created by this pathogen. Looking into its
Comparative study of herbal plants on the phenolic and flavonoid content, antioxidant activities and toxicity on cells and zebrafish embryo.
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Natural antioxidants derived from plants have shown a tremendous inhibitory effect on free radicals in actively metabolizing cells. Overproduction of free radicals increases the risk factor of chronic diseases associated with diabetes, cancer, arthritis and cardiovascular disease. Andrographis
The effects of wine-processing on ascending and descending: The distribution of flavonoids in rat tissues after oral administration of crude and wine-processed Radix scutellariae.
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BACKGROUND
Ascending and descending theory is a core principle of traditional Chinese medicine (TCM) theories. It plays an essential role in TCM clinical applications. Some TCM medicine has specific properties, which could alter the inclination and direction of their actions. The properties of the
Quercetin and tamoxifen sensitize human melanoma cells to hyperthermia.
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Hyperthermia produces regression of human cancer. Because hyperthermia has produced only limited results, attention has focused on searching for substances able to sensitize tumour cells to the effects of hyperthermia. The flavonoid quercetin has been reported to be a hyperthermic sensitizer in
Quercetin and hyperthermia produce a synergistic inhibitory effect on primary human ovarian-cancer cells.
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Quercetin (from 0.1 muM to 10 muM) produced a dose dependent inhibition of colony formation of cells from 4 primary ovarian tumors expressing type II estrogen binding sites (type II EBS).The combined effects of quercetin ( 10 muM) and hyperthermia (42-degrees-C) result in a significant synergistic
[IE and IgG antibodies against flavonoids following therapy with flavonoid-containing drugs].
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During treatment with flavonoid drugs a number of patients developed adverse reactions such as fever, various skin eruptions and intravascular hemolysis. The appearance of flavonoid-specific IgE and IgG antibodies and its possible relation to the observed side effects was studied on a total of 168
Qualitative and Quantitative Analysis of Phenolic Acids, Flavonoids and Iridoid Glycosides in Yinhua Kanggan Tablet by UPLC-QqQ-MS/MS.
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A simple, rapid and specific ultra-performance liquid chromatography-triple quadrupole mass spectrometry method was developed for the analysis of 29 bioactive components (10 phenolic acids, 16 flavonoids, and three iridoid glycosides) in Yinhua Kanggan tablet (YHKGT), a herbal prescription used for
Total phenolic, flavonoid, alkaloid and iridoid content and preventive effect of Lider-7-tang on lipopolysaccharide-induced acute lung injury in rats.
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Lider-7-tang, a medicine used for the treatment of respiratory diseases especially pneumonia and fever in Mongolian Traditional Medicine, was selected for this phytochemical and pharmacological study. The objectives of the study were to determine total biological active substances and analyze the
The pathogenesis of cianidanol-induced fever.
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Recently, there has been a variety of reports of adverse drug reactions during therapy with the flavonoid Cianidanol (Ci), a cytoprotective radical scavenger, especially involving haemolytic anaemia and drug fever. To elucidate whether the fever was due to a direct, antigen-independent interaction
Smooth muscle relaxing flavonoids from Alchornea cordifolia.
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Alchornea cordifolia (Schum. & Thonn.) Muell. Arg. (Euphobiaceae) is widely distributed throughout tropical Africa, where it is used extensively in traditional medicine. Conditions for which the plant has enjoyed wide use are: coughs, gonorrhoea, yaws, ulcer, rheumatic pains, fever and bronchial
Chemical Profiling and Characterization of Phenolic Acids, Flavonoids, Terpene Glycosides from Vangueria agrestis using Ultra-High Performance Liquid Chromatography/Ion Mobility Quadrupole Time-of-Flight Mass Spectrometry and Metabolomics Approach.
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Vangueria agrestis is a shrub indigenous to tropical Africa, belonging to family Rubiaceae and traditionally is used as a decoction for treatment of fever, pain and malaria. The current study was undertaken to investigate the chemical constituents based on precursor exact mass and fragment ion
Simultaneous Determination of 10 Flavonoids in Crude and Wine-Processed Radix scutellariae by UHPLC.
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Radix scutellariae is a well-known traditional Chinese medicine used for the treatments of inflammation, pyrexia, hepatitis, etc. Flavonoids are its main active compounds. The aim of this study is to develop and validate the ultra high-performance liquid chromatography (UHPLC) method for
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