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9 hasil
18F-labelled folates
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FIELD OF INVENTION
The present invention is directed towards new .sup.18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their
.sup.18F-labelled folates
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FIELD OF INVENTION
The present invention is directed towards a new method of synthesis of .sup.18F-labeled pteroate or folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with .sup.18[F]fluoride, as well as
.sup.18F-labelled folates
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FIELD OF INVENTION
The present invention is directed towards new .sup.18F-folate radiopharmaceuticals, wherein fluorine-18 is covalently linked to the aminobenzoyl moiety, which connects the condensed pyrimidine heterocycle to the amino acid portion within folate structures, as well as their
18F-labelled folate/antifolate analogues
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FIELD OF INVENTION
The present invention is directed towards new .sup.18F-folate/antifolate analogue radiopharmaceuticals, wherein the phenyl group within a folate structure, has been replaced by an .sup.18F-heterocycle, their precursors, a method of their preparation, as well as their use in
.sup.18F-saccharide-folates
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FIELD OF INVENTION
The present invention is directed towards new .sup.18F-folate radiopharmaceuticals, wherein the .sup.18F isotope is linked via a prosthetic group, more specifically via a prosthetic group comprising a saccharide group, such as cyclic mono- and oligosaccharides, which is covalently
Anti-human folate receptor beta antibodies and methods of use
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SEQUENCE LISTING
A sequence listing in electronic (ASCII text file) format is filed with this application and incorporated herein by reference. The name of the ASCII text file is "AttachE_Sequence_Listing.txt"; the file was created on Apr. 8, 2016; the size of the file is 17 KB.
TECHNICAL FIELD
This
Anti-human folate receptor beta antibodies and methods of use
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TECHNICAL FIELD
This invention relates to anti-folate receptor beta (FR.beta.) antibodies, and more particularly to human monoclonal antibodies, or antigen-binding fragments thereof, that specifically bind human FR.beta. and methods of using such antibodies or antigen binding fragments thereof to
Anti-human folate receptor beta antibodies and methods of use
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TECHNICAL FIELD
This invention relates to anti-folate receptor beta (FR.beta.) antibodies, and more particularly to human monoclonal antibodies, or antigen-binding fragments thereof, that specifically bind human FR.beta. and methods of using such antibodies or antigen binding fragments thereof to
Metabolically inert anti-inflammatory and anti-tumor antifolates
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FIELD OF INVENTION
This invention relates to folic acid antagonists that are metabolically inert exhibiting a high level of anti-inflammatory and anti-tumor activity. Metabolically inert classical antifolates are new and therefore they exhibit unexpected biological properties such as those recited
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