Omega-3 group (n=30) received capsules containing 945 mg of Omega-3 PUFA [α linolenic acid/ 64%, eicosapentaenoic acid (EPA)/16% and docosahexaenoic acid (DHA)/21%], in 3 capsules/ day

Fatty Liver

Omega 3

University of Sao Paulo School of Medicine

Omega 3 Supplementation in Fatty Liver

Polyunsaturated Fatty Acid (Pufa) Omega 3 in the Reduction of the Inflammatory Component of the Nonalcoholic Steatohepatitis (Nash):Randomized Placebo Controlled Study

Determine the efficacy of Omega-3 fatty acid in reducing the inflammatory component of NASH for liver through liver biopsy NAS score.

Measure TNFalfa, IL6, adiponectin, lipidic leuckocyte profile, EPA (eicosapentaenoic acid), DHA (docosahexaenoic) and laboratory tests AST, ALT, Cholesterol, total triglycerides, PCR, VHS, SAA.

Claudia Pinto Marques Oliveira

University of Sao Paulo General Hospital

Head and Neck Cancer

Recently, a polymerase chain reaction (PCR) -based hypoxia classifier gene signature was published that can be easily applied. Using this classifier, patients will be divided in hypoxic or non-hypoxic subgroups.
These subgroups will be correlated to locoregional control. The hypoxic signature will also be related to parameters on DCE-MRI, DWI and FDG-PET.

A polymerase chain reaction -based hypoxia classifier

As part of the standard staging procedure all patients will undergo an MRI of the neck. We will however also take DWI and DCE images at this time point. Parameters of these images will be later on correlated with pathology.

Functional imaging before treatment.

At 3 levels of the tumour, chosen by the radiologist on the functional imaging modalities, 4µm thick slices will me taken. On each level an immunohistochemical staining will be carried out (GLUT-1, CA-IX, HIF-1alpha, VEGF, KI 67). The result of this staining will be correlated with parameters derived from the functional imaging modalities.

Immunohistochemical staining

To account for the shrinkage of the tumour due to fixation, the resection specimen will be placed in a box and scanned with an MRI. From this a shrinkage factor will be calculated using the original pre-treatment MRI.

MRI of the resection specimen

On the imaging modalities the tumor volume will be delineated. This will also be done on the resection specimen. Later on the different tumour volumes will be correlated.

Tumour volume delineation and comparison

Radiation Oncology

Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma

Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma. A Prospective, Non-commercial and Mono-centric Study

The correlation of DWI, DCE-MRI and FDG-PET with the spatial distribution of hypoxia in patients with head and neck cancer.

Dr. Sandra Nuyts

Full Professor, Clinical staff member

Universitaire Ziekenhuizen Leuven

Flemish League Against Cancer

CHF patients were identified from inpatients as well as patients attending outpatient clinics and from the general practice in the community. Diagnosis of CHF was based on the European Society of Cardiology guidelines for CHF. All patients with stable CHF were included in the study. Inpatients with CHF who were hospitalized were also included, except patients with acutely decompensated CHF requiring intravenous therapy. CHF patients with a previous diagnosis of diabetes mellitus were excluded from the study.

A group of healthy subjects were also studied. They were recruited from the community and were clinically healthy based on history, physical examination, and blood laboratory results and were not taking any medication.

Congestive Heart Failure

Heart Failure

University of Dundee

Insulin Resistance : Heart Failure

Insulin Resistance: A New Target in Heart Failure

Fasting insulin resistance index was assessed in a cohort of 129 consecutive CHF patients testing and peripheral endothelial function testing by reactive hyperemia peripheral arterial tonometry (RH-PAT).

blood flow to the liver will be cut off by hilar clamping for ten minutes followed by release of the clamp prior to removal of the liver from the donor.

Liver Cirrhosis

Liver Disease

Experimental: Hepatic Ischemic Preconditioning blood flow to the liver will be cut off by hilar clamping for ten minutes followed by release of the clamp prior to removal of the liver from the donor.

formaldehyde/nekrosis

Omega 3 Supplementation in Fatty Liver

Pathological Validation of Functional Imaging in Head and Neck Squamous Cell Carcinoma

Insulin Resistance : Heart Failure

Ischemic Preconditioning of Liver in Cadaver Donors

Research in Skin Inflammation

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