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Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer.

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Frequent allelic loss of the chromosomal region 17p13 in breast cancer has suggested that more tumor suppressor genes, besides p53, are located in this region. By doing suppression subtractive hybridization to detect differentially expressed genes between the breast cancer cell line CAL51 and a

Breast cancer brain metastases: evidence for neuronal-like adaptation in a 'breast-to-brain' transition?

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Brain metastases remain a significant challenge in the treatment of breast cancer patients due to the unique environment posed by the central nervous system. A better understanding of the biology of breast cancer cells that have metastasized to the brain is required to develop improved therapies. A

A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding.

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The pathogenesis of breast cancers that do not express estrogen receptors or Her-2/neu receptors (ER-/HER2- phenotype) is incompletely understood. We had observed markedly elevated gene expression of gamma-aminobutyric acid type A (GABA(A)) receptor subunit pi (GABApi, GABRP) in some breast cancers

Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue.

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The GABRP gene has been previously identified by in silico analysis of four million ESTs as a candidate gene differentially expressed in breast cancer. GABRP is located on chromosome 5q34 and it encodes the pi-subunit of the gamma-aminobutyric acid (GABA) receptor, a transmembrane protein expressed

Spontaneous vesicle formation by γ-aminobutyric acid derived steroidal surfactant: Curcumin loading, cytotoxicity and cellular uptake studies.

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Cholesterol (Chol) is a ubiquitous steroidal component of cell membrane and is known to modulate the packing of phospholipids within the bilayer. Thus, Chol has been frequently used in the formulation and study of artificial "model membranes" like vesicles and liposomes. In this work, we have

A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells.

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Mounting evidence suggests that metformin (N,N-dimethylbiguanide), a widely prescribed drug for the treatment of type II diabetes, exerts an anti-tumor effect on several cancers including breast cancer. Breast cancer has been estimated as one of the most commonly diagnosed types of cancer among

Identification of Methylation Markers and Differentially Expressed Genes with Prognostic Value in Breast Cancer.

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Breast cancer is one of the most common cancers causing a high mortality worldwide. This study aimed to identify differential methylation and expression genes with prognostic value in breast cancer. DNA methylation and gene expression profiles (GSE60185, GSE42568, GSE21653, GSE58812, and

Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breast cancer.
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OBJECTIVE We examined the feasibility of using molecular characterization of circulating tumor cells as a method for early detection of breast cancer. METHODS Women without a prior history of cancer who had a breast abnormality detected on imaging followed by a breast biopsy were enrolled in this

GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation.
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The present study aims to determine the role of γ-aminobutyric acid (GABA) signaling molecules in breast cancer metastasis. Our results reveal that GABAergic system exists in breast cancer cells. Both the GABA synthetic enzyme. (GAD65/67) and GABAB receptor are expressed in 4T1 mouse breast cancer

Chemical constituents and anticancer activity of yellow camellias against MDA-MB-231 human breast cancer cells.
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Yellow camellia, with its golden yellow flowers, is rare in the world. Most studies of yellow camellia have focused on its ornamental properties; however, there are fewer published studies on its medical values. The purpose of this study was to define the chemical constituents and the biological

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray.
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While the autophagic process is mainly regulated at the post-translational level, a growing body of evidence suggests that autophagy might also be regulated at the transcriptional level. The identification of transcription factors involved in the regulation of autophagy genes has provided compelling

Neurotransmissions of antidepressant-like effects of kisspeptin-13.
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Kisspeptins are G protein-coupled receptor ligands originally identified as human metastasis suppressor gene products that have the ability to suppress melanoma and breast cancer metastasis and which have recently been found to play an important role in initiating the secretion of

Melatonin deficiencies in women.
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The pineal hormone melatonin is the mediator of external light to physiologic adaptation to day and night rhythms, it regulates reproduction in animals but attempts to utilize melatonin in women for contraception have failed. Melatonin seems to be the natural hormone to facilitate sleep in insomniac

The role of GABA-ergic system in human mammary gland pathology and in growth of transplantable murine mammary cancer.
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In this paper we described the results of our studies on the baclophen (gamma aminobutyric acid (GABA)-B receptor agonist) inhibitory effect on the growth of experimental mammary cancer 16/C in mice and on the estimation of GABA level and GAD (glutamine acid decarboxylase--the key enzyme in GABA

Differential estrogenic effects of the persistent organochlorine pesticides dieldrin, endosulfan, and lindane in primary neuronal cultures.
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The organochlorine chemicals endosulfan, dieldrin, and γ-hexachlorocyclohexane (lindane) are persistent pesticides to which people are exposed mainly via diet. Their antagonism of the γ-aminobutyric acid-A (GABA(A)) receptor makes them convulsants. They are also endocrine disruptors because of their

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Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer.

Breast cancer brain metastases: evidence for neuronal-like adaptation in a 'breast-to-brain' transition?

A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding.

Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue.

Spontaneous vesicle formation by γ-aminobutyric acid derived steroidal surfactant: Curcumin loading, cytotoxicity and cellular uptake studies.

A novel metformin derivative, HL010183, inhibits proliferation and invasion of triple-negative breast cancer cells.

Identification of Methylation Markers and Differentially Expressed Genes with Prognostic Value in Breast Cancer.

Evaluation of a panel of tumor markers for molecular detection of circulating cancer cells in women with suspected breast cancer.

GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation.

Chemical constituents and anticancer activity of yellow camellias against MDA-MB-231 human breast cancer cells.

The acquisition of resistance to TNFα in breast cancer cells is associated with constitutive activation of autophagy as revealed by a transcriptome analysis using a custom microarray.

Neurotransmissions of antidepressant-like effects of kisspeptin-13.

Melatonin deficiencies in women.

The role of GABA-ergic system in human mammary gland pathology and in growth of transplantable murine mammary cancer.

Differential estrogenic effects of the persistent organochlorine pesticides dieldrin, endosulfan, and lindane in primary neuronal cultures.

Database tanaman obat terlengkap yang didukung oleh sains