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Electrophysiological effects of antidepressants on mammalian hearts and crayfish giant axon.
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Cardiotoxicity is known to occur in patients with or without preexisting cardiac diseases during treatments with the tricyclic antidepressants, amitriptyline and imipramine. The antiarrhythmic action of tricyclics was also demonstrated in clinical studies and in animal experiments. Bupropion, a
Actions of the antidepressant drug imipramine on the voltage-clamped Myxicola giant axon.
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The effects of the antidepressant drug imipramine were studied on the voltage-clamped Myxicola giant axon at concentrations from 10- minus 6 to 5 X 10- minus 5 M. Over this range, imipramine reversibly reduced both the sodium and potassium conductances without having any substantial effect on either
Psychotic depression due to giant condyloma Buschke-Löwenstein tumors.
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A 63-year-old patient, with no psychiatric history, was admitted in the psychiatric department with depressed mood, loss of interest in activities, apathy, insomnia, attention deficit, irritability, social withdrawal, prejudice and abandon delusions. Cerebral computed tomography (CT) scan was normal
Giant cell arteritis presenting as depressed mood and headache in an elderly patient.
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Giant cell arteritis (GCA) is an autoimmune disorder characterized by the inflammation of medium to large vessels. Although classic descriptions have centered on features such as vision loss, headaches, fevers, and jaw claudication, there is increasing recognition of more atypical manifestations. We
Dermatitis artefacta.
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BACKGROUND
Dermatitis artefacta (DA) is difficult to diagnose by clinical findings alone. Histopathologic analysis may rule out organic disorders and in some cases establish, in conjunction with microanalytic techniques, a definite diagnosis.
OBJECTIVE
We report a young woman with DA in the form of
The types of headache that affect the elderly.
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Older people often describe their headaches as starting with vague neck discomfort and eventually moving to the temples and forehead. These are muscle-tension headaches, by far the most common type in the elderly. Although cervical osteoarthritis often is at fault, depression can be a significant
The purified mechanosensitive channel TREK-1 is directly sensitive to membrane tension.
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Mechanosensitive channels are detected in all cells and are speculated to play a key role in many functions including osmoregulation, growth, hearing, balance, and touch. In prokaryotic cells, a direct gating of mechanosensitive channels by membrane tension was clearly demonstrated because the
Non-classical mechanism of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor channel block by fluoxetine.
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Antidepressants have many targets in the central nervous system. A growing body of data demonstrates the influence of antidepressants on glutamatergic neurotransmission. In the present work, we studied the inhibition of native Ca(2+)-permeable and Ca(2+)-impermeable
Complications of varicella zoster virus reactivation.
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UNASSIGNED
Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after which virus becomes latent in ganglionic neurons along the entire neuraxis. With advancing age or immunosuppression, cell-mediated immunity to VZV
Fluoxetine impairs GABAergic signaling in hippocampal slices from neonatal rats.
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Fluoxetine (Prozac), an antidepressant known to selectively inhibit serotonin reuptake, is widely used to treat mood disorders in women suffering from depression during pregnancy and postpartum period. Several lines of evidence suggest that this drug, which crosses the human placenta and is secreted
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