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giant/imunostimulator
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Danger signaling protein HMGB1 induces a distinct form of cell death accompanied by formation of giant mitochondria.
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Cells dying by necrosis release the high-mobility group box 1 (HMGB1) protein, which has immunostimulatory effects. However, little is known about the direct actions of extracellular HMGB1 protein on cancer cells. Here, we show that recombinant human HMGB1 (rhHMGB1) exerts strong cytotoxic effects
[Therapeutic pathomorphosis. Effect of immunostimulator levamisole on the morphology of specific inflammation under experimental conditions].
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When levamisol was added to the antituberculosis therapy of rabbits with destructive pulmonary tuberculosis, intensive infiltration of the zone of lesions with polymorphonuclear cells and their accumulation in cavities, increased numbers of giant multinuclear cells, "macrophage" transformation of
Immunostimulatory effects of collagen from jellyfish in vivo.
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We focused on the biological activity of the collagen extracts obtained from the giant edible jellyfish, Nemopilema nomurai. Jellyfish collagen extracts stimulates the production of immunoglobulins (Igs) and cytokines by human hybridoma cells and human peripheral blood lymphocytes. Therefore, we
Membrane interactions of proline-rich antimicrobial peptide, Chex1-Arg20, multimers.
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The increasing prevalence of antibiotic-resistant pathogens requires the development of new antibiotics. Proline-rich antimicrobial peptides (PrAMPs), including native apidaecins, Bac7, and oncocins or designed A3APO, show multi-modal actions against pathogens together with immunostimulatory
Expedient synthesis of functional single-component glycoliposomes using thiol-yne chemistry.
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The preparation of a set of eight unprecedented amphiphilic neoglycolipids forming liposome nanoparticles is reported. The small library was readily obtained from various peracetylated propargyl glycopyranosides via efficient radical-initiated thiol-yne (TYC) coupling reactions using alkanethiols of
A probiotic Bacillus strain containing amorphous poly-beta-hydroxybutyrate (PHB) stimulates the innate immune response of Penaeus monodon postlarvae.
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In this study, the PHB-accumulating Bacillus sp. JL47 strain (capable of accumulating 55% PHB on cell dry weight) was investigated for its effects on the immune response of giant tiger shrimp (Penaeus monodon) postlarvae (PL) before and after the Vibrio campbellii challenge. Briefly, shrimp PL were
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