glioblastoma/seizures

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Incidence, Characteristics, and Implications of Seizures in Patients With Glioblastoma.

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BACKGROUND Seizures in patients with glioblastoma are associated with worse quality of life. However, their incidence, clinical characteristics, and prognostic implications are less well characterized. OBJECTIVE This study was undertaken to provide a contemporary experience along with benchmark data

Temozolomide and seizure outcomes in a randomized clinical trial of elderly glioblastoma patients

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Introduction: Tumor-related epilepsy may respond to chemotherapy. In a previously-published multi-centre randomized clinical trial of 562 elderly glioblastoma patients, temozolomide plus short-course radiotherapy conferred a survival

Seizure-Susceptible brain regions in glioblastoma: identification of patients at risk.

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The main aim of this study was to identify which patients with glioblastoma multiforme (GBM) have a higher risk of presenting seizures during follow-up. Patients with newly diagnosed GBM were reviewed (n = 306) and classified as patients with (Group 1) and without (Group 2) seizures at onset. Group

Seizures as presenting symptom in patients with glioblastoma.

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The clinical course and underlying molecular causes in patients with glioblastoma presenting with seizures are poorly understood. Here we investigated clinical features and carrier systems as well as a transaminase relevant in glutamate homeostasis in patients with

Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures.

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Purpose: Seizures related to tumor growth are common in glioma patients, especially in low-grade glioma patients this is often the first tumor manifestation. We hypothesize that there are associations between preoperative seizures and morphologic features (e.g., tumor size, location) and

Tumor associated seizures in glioblastomas are influenced by survival gene expression in a region-specific manner: a gene expression imaging study.

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Tumor associated seizures (TAS) are common and cause significant morbidity. Both imaging and gene expression features play significant roles in determining TAS, with strong interactions between them. We describe gene expression imaging tools which allow mapping of brain regions where gene expression

Glioblastoma Multiforme in a Patient with Celiac Disease: Management of Seizures After Gross Total Tumor Resection.

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BACKGROUND A 55-year-old woman with a history of celiac disease presented with focal seizures and a mass lesion located at the left frontal lobe. Management of seizures in these patients is challenging. METHODS The patient underwent a navigation-assisted tumor resection. A week later, she returned

Improved Survival with Decreased Wait Time to Surgery in Glioblastoma Patients Presenting with Seizure.

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BACKGROUND Preoperative seizure is reported to confer favorable prognosis in glioblastoma patients, but studies to date have not investigated how broadly applicable seizure is as a prognostic factor. OBJECTIVE To investigate if prompter surgical intervention affects the relationship between

Prognostic significance of seizure in patients with glioblastoma multiforme.

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BACKGROUND Several prognostic factors have been described but there are few studies evaluating the prognostic importance of seizure in patients with glioblastoma multiforme (GBM). OBJECTIVE To evaluate the prognostic importance of seizure at the time of the diagnosis of glioblastoma multiforme (GBM)

Head trauma and seizures as risk factors of glioblastoma.

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This is a case-control study of 160 persons with glioblastoma and 128 of their "best friends" as controls. Subjects came mainly from greater Boston, and data were gathered by questionnaire and telephone interview. Among those who had had a "severe" head injury at age 15 or later, the age-adjusted

Why dapsone stops seizures and may stop neutrophils' delivery of VEGF to glioblastoma.

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Lopez-Gomez et al. recently published remarkable but mechanistically unexplained empirical evidence that the old antibiotic dapsone has antiepileptic activity. We addressed the question "Why should a sulfone antibiotic reduce seizures?". We report here our conclusions based on data from past studies

Quantifying the prognostic significance in glioblastoma of seizure history at initial presentation: A systematic review and meta-analysis.

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The role of prognostic factors in the management of glioblastoma (GBM) is very important given the stasis in improving its clinical outcomes. Patients who initially present with a positive seizure history at diagnosis have anecdotally experienced superior survival outcomes. The aim of this review

Epileptic features and survival in glioblastomas presenting with seizures.

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The prognostic value of seizures in patients with glioblastoma is currently under discussion. The objective of this research was to study the risk factors associated with seizures occurring at the diagnosis of glioblastoma and the role of seizures as a predictive factor for survival. We

Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme.

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BACKGROUND To examine the efficacy of valproic acid (VPA) given either with or without levetiracetam (LEV) on seizure control and on survival in patients with glioblastoma multiforme (GBM) treated with chemoradiation. METHODS A retrospective analysis was performed on 291 patients with GBM. The

Different aquaporin-4 expression in glioblastoma multiforme patients with and without seizures.

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Aquaporin-4 (AQP-4), the most important water channel in the brain, is expressed by astrocyte end feet abutting microvessels. Altered expression levels of AQP-4 and redistribution of the protein throughout the membranes of cells found in glioblastoma multiforme (GBM) lead to development of the edema

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