Serum and cerebrospinal fluid if available. Microdialysis samples.

Traumatic Brain INjury

Microdialysis

Cambridge University Hospital NHS Trust

TBI Multimodal Monitoring Study

Multimodality Monitoring Directed Management of Patients Suffering From Traumatic Brain Injury

Decrease of lactate:pyruvate ratio to below 25

How many patients have the different pathological targets, including 1. Intracranial hypertension (LPR corrected if ICP <20mmHg), 2. Delivery failure (if LPR is corrected when PbO2 is improved and CPP increased). 3.Oxygen Diffusion Barrier (LPR is corrected if PbO2 is increased through FiO2 increase). 4. Neuroglycopenia (LPR is corrected if brain glucose is increased) or 5. Mitochondrial dysfunction (LPR remains increased despite all the therapies applied).

Correlation between Microdialysis parameters (glucose (mmol/L), lactate (mmol/L), pyruvate (mmol/L) and glutamate (µmol/L)) and PbO2 (mmHg), ICP (mmHg) and CPP (mmHg)

extended Glasgow Outcome Score 6 months following trauma assessed in the outpatient clinic at Addenbrooke's Hospital. Comparison between patients in different pathological targets.

Amount of cytokine concentration in microdialysis sample. Comparison between patients in different pathological targets.

Amount of S100B concentration (µg/L) through serum samples taken twice daily in the neuro-critical care unit. Comparison between patients in different pathological targets.

Adel Helmy

University Lecturer Neurosurgery

University of Cambridge

Cambridge University Hospitals NHS Foundation Trust

Obstructive Sleep Apnea

Chronic Obstructive Pulmonary Disease

Obesity

Texas A&M University

Fat Metabolism in OSA and COPD

Fat Metabolism and Digestion in Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease

changes in hepatic triglyceride synthesis before and after a meal

changes in hepatic de novo lipogenesis before and after a meal

changes in adipose tissue triglyceride synthesis before and after a meal

changes in adipose tissue de novo lipogenesis before and after a meal

changes in adipose tissue lipolysis before and after a meal. plasma enrichment of glycerol.

determine changes in appearance of glucose rate in subjects

Determine whole body glucose production in subjects

Determine whole body glucose uptake in subjects

change in whole-body protein synthesis rate after intake of meal

defining fat digestion and absorption after a meal. Enrichment in palmitic acid and tripalmitin fatty acids in plasma

acute changes from postabsorptive state to postprandial state

body composition will be determined by dual-energy X-ray absorptiometry and by deuterated water dilution technique. Plasma deuterium enrichments will be determined.

Outcome of physical activity assessment in breast cancer patients and healthy controls in relation to the fat metabolism

Ratio enrichment free phenylalanine vs phenylalanine from protein spirulina

Marielle PKJ Engelen, PhD

Associate Professor

Continuous i.v. infusion of Sodium Lactate (2'400 mOsmol/L) over 3 hours

Traumatic Brain Injury

Subarachnoid Hemorrhage

3-6 hours continuous infusion of sodium lactate (20-40 mcg/kg/min)

sodium lactate infusion

CHUV, Lausanne University Hospital

Lactate Therapy After Traumatic Brain Injury

Neuroprotective Role of Lactate Therapy in Humans With Traumatic Brain Injury

Increase from baseline in brain extracellular lactate, pyruvate and glucose measured with intra-parenchymal cerebral microdialysis catheter

glycerol/hypoxia

TBI Multimodal Monitoring Study

Fat Metabolism in OSA and COPD

Lactate Therapy After Traumatic Brain Injury

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