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gout/obesitas

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Method for combating obesity

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The present invention relates to a method for controlling obesity and diseases caused by obesity. The peptide hormone endothelin is known for its strong vasoconstrictor properties. Endothelin receptor antagonists are therefore mainly being tested in cardiovascular pathologies. The invention relates

Pyrazolopyridine compound and processes for preparation thereof

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The present invention relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof. More particularly, it relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof, which are adenosine antagonists and possess various pharmaceutical actions

Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-.alpha. modulators

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FIELD OF THE INVENTION The present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and for treating conditions such as cancer, arthritis, inflammatory airway disease, and metabolic disorders. More particularly, the
TECHNICAL FIELD The present invention focuses on definition of pharmaceutical compositions and proposed method for the treatment of metabolic syndrome, diabetes mellitus and aging. Compounds and compositions of natural origin are disclosed in the description. More particularly, this invention

Ketohexokinase (KHK) iRNA compositions and methods of use thereof

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SEQUENCE LISTING The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Jul. 28, 2016, is named Seq_Listing_121301_01202.txt and is 116,250 bytes in

Compositions and methods for the treatment of metabolic syndrome

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PRIORITY This application is a national phase filing of the Patent Cooperation Treaty (PCT) application # PCT/IB2013/050904 titled COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME filed on Feb. 3, 2013 Published with WIPO Publication # WO/2013/167996, which further claims priority to

Compositions and methods for the treatment of metabolic syndrome

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PRIORITY The present application claims the benefit of Indian Provisional Patent Application No. 1836/CHE/2012 filed on 10 May 2012 and the International Application No. PCT/IB2013/050907 filed on 3 Feb. 2013; the entire disclosure of which is relied on for all purposes and is incorporated into this

SGLT-2 inhibitors, methods of making them, and uses thereof

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FIELD OF THE INVENTION The present invention relates to compounds which are inhibitors of sodium dependent glucose co-transporter-2 (SGLT-2), methods of making them, and uses thereof. BACKGROUND OF THE INVENTION According to the World Health Organization (WHO), in 2009, more than 220 million people

Pyridone derivatives

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This application is a U.S. national stage of International Application No. PCT/JP03/03115 filed Mar. 14, 2003. TECHNICAL FIELD The present invention is useful in medical fields. In more detail, novel pyridone derivatives of the present invention have an effect as neuropeptide Y receptor antagonists

Piperidine derivative

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CROSS REFERENCE TO RELATED APPLICATIONS This application is a U.S. National Phase application under 35 U.S.C. .sctn. 371 of PCT Application No. PCT/JP2004/013768, filed Sep. 21, 2004, which claims priority under 35 U.S.C. .sctn. 119 from Japanese Application No. JP2003-330758, filed Sep. 22,

Piperidine derivative

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TECHNICAL FIELD The present invention relates to a novel piperidine derivative, to a histamine-H3 receptor antagonist containing the novel piperidine derivative as an active ingredient thereof, and to a preventive or remedy for metabolic system diseases, circulatory system diseases, central or

Pyrazolopyridine compounds which have useful pharmaceutical utility

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The present invention relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof. More particularly, it relates to novel pyrazolopyridine compound and a pharmaceutically acceptable salt thereof, which are adenosine antagonists and posses various pharmaceutical actions

Substituted phenoxy N-alkylated thiazolidinediones as estrogen related receptor-.alpha. modulators

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FIELD OF THE INVENTION The present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and for treating conditions such as cancer, arthritis, inflammatory airway disease, and metabolic disorders. More particularly, the

Substituted phenoxy N-alkylated thiazolidinediones as estrogen related receptor-.alpha. modulators

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FIELD OF THE INVENTION The present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and for treating conditions such as cancer, arthritis, inflammatory airway disease, and metabolic disorders. More particularly, the

Substituted phenoxy thiazolidinediones as estrogen related receptor-a modulators

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FIELD OF THE INVENTION The present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and for treating conditions such as cancer, arthritis, inflammatory airway disease, and metabolic disorders. More particularly, the
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