BACKGROUND
Adrenal androgen excess is common in polycystic ovary syndrome (PCOS) and appears to be heritable. CYP3A7 metabolizes dehydroepiandrosterone and its sulfate (DHEAS). A promoter variant, CYP3A7*1C, which results in persistent expression in adults, was associated with reduced DHEAS levels
Interview by Rona Williamson Ricardo Azziz, MD, MPH, MBA, is Professor of Obstetrics and Gynecology (Ob/Gyn), Medicine and Medical Humanities, and President, at Georgia Regents University and CEO of the Georgia Regents Health System, Augusta, GA, USA. Georgia Regents University is one of Georgia's