Provided are novel compounds that are useful in the prevention or treatment of such diseases as dementia, Alzheimer's disease, attention-deficient hyperactivity disorder, schizophrenia, epilepsy, central convulsion, obesity, diabetes mellitus, hyperlipidemia, narcolepsy, idiopathic hypersomnia, behaviorally induced insufficient sleep syndrome, sleep apnea syndrome, circadian rhythm disorder, parasomnia, sleep related movement disorder, insomnia, and depression, or allergic rhinitis, or pharmaceutically acceptable salts of such compounds. Specifically, there are provided phenylpyrrole compounds represented by the following formula (I) or pharmaceutically acceptable salts thereof: Formula (I) ##STR00001## [wherein Q refers to a group represented by the following formula (A) or (B): ##STR00002##

TAISHO PHARMACEUTICAL CO., LTD

Phenylpyrrole derivative

Compounds represented by the general formula (I): ##STR00001## wherein Ar.sup.1 and Ar.sup.2 are each aryl or heteroaryl; R.sup.1 is lower cycloalkyl, --Ar.sup.3, or a group of the general formula (a), (b) or (c): ##STR00002## and R.sup.2 and R.sup.3are each hydrogen, lower cycloalkyl, lower alkenyl, or optionally substituted lower alkyl (with the proviso that when R.sup.2 and R.sup.3 are simultaneously hydrogen, Ar.sup.1, Ar.sup.2 and R.sup.1 do not simultaneously represent unsubstituted phenyl). The compounds are useful as treating agents for various NPY-related diseases, for example, circulatory diseases including hypertension, kidney diseases, cardiac diseases, vasospasm and arteriosclerosis; central nervous system diseases including hyperphagia, depression, anxiety, convulsion, epilepsy, dementia, pain, alcohol dependence, and withdrawal symptoms due to abstinence from drugs; metabolic diseases including obesity, diabetes, hormonal disorders, hypercholesterolemia, and hyperlipidemia; sexual dysfunction and reproductive function disorders; digestive diseases including enterokinetic disorders; respiratory diseases; inflammation; or glaucoma.

Banyu Pharmaceutical Co., Ltd.

Imidazoline compounds

Compounds represented by the general formula (I): ##STR00001## wherein Ar.sup.1 and Ar.sup.2 are each aryl or heteroaryl; R.sup.1 is lower cycloalkyl, --Ar.sup.3, or a group of the general formula (a), (b) or (c): ##STR00002## and R.sup.2 and R.sup.3 are each hydrogen, lower cycloalkyl, lower alkenyl, or optionally substituted lower alkyl (with the proviso that when R.sup.2 and R.sup.3 are simultaneously hydrogen, Ar.sup.1, Ar.sup.2 and R.sup.1 do not simultaneously represent unsubstituted phenyl). The compounds are useful as treating agents for various NPY-related diseases, for example, circulatory diseases including hypertension, kidney diseases, cardiac diseases, vasospasm and arteriosclerosis; central nervous system diseases including hyperphagia, depression, anxiety, convulsion, epilepsy, dementia, pain, alcohol dependence, and withdrawal symptoms due to abstinence from drugs; metabolic diseases including obesity, diabetes, hormonal disorders, hypercholesterolemia, and hyperlipidemia; sexual dysfunction and reproductive function disorders; digestive diseases including enterokinetic disorders; respiratory diseases; inflammation; or glaucoma.

Banyu Pharmaceutical, Co., Ltd.

Imidazonline compounds

Compounds of the formula (I): ##STR00001## (wherein A is an optionally substituted straight-chain hydrocarbon having 1 to 6 carbon atoms, which is optionally intervened by oxygen or nitrogen atom; Ar.sup.1 is aryl or heteroaryl, any of which is optionally substituted; n is 0 or 1; R.sup.0 is hydrogen, or lower alkylene attached to an arbitrary, bondable position of A; T, U, V and W are independently nitrogen atom or optionally substituted methine, and at least two of T, U, V and W are said methine group; X is --N(SO.sub.2R.sup.1)--, --N(COR.sup.2)-- or --CO--; Y is --C(R.sup.3)(R.sup.4)--, --O-- or --N(R.sup.5)--; Z is methine or nitrogen atom) exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, etc., metabolic diseases such as obesity, diabetes, hormone abnormality, hypercholesterolemia, hyperlipidemia, etc., sexual and reproductive dysfunctions, and gastro-intestinal motility disorder.

Spiro compounds

PROBLEM To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. SOLUTION A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I). ##STR00001##

hyperlipidemias/seizures

Phenylpyrrole derivative

Imidazoline compounds

Imidazonline compounds

Spiro compounds

7-piperidinoalkyl-3, 4-Dihydroquinolone derivative

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