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hyponatremia/sembap
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14 hasil
Substituted spirobenzazepines
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FIELD OF THE INVENTION
This invention relates to novel nonpeptide substituted spirobenzazepines useful as, for example, vasopressin receptor antagonists.
BACKGROUND OF THE INVENTION
Vasopressin is a nonpeptide hormone that is secreted primarily from the posterior pituitary gland. The hormone effects
Substituted spiroheterocycles
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FIELD OF THE INVENTION
This invention relates to novel nonpeptide substituted spiroheterobenzazepines useful as, for example, vasopressin receptor antagonists.
BACKGROUND OF THE INVENTION
Vasopressin is a nonapeptide hormone that is secreted primarily from the posterior pituitary gland. The hormone
Substituted spiroheterocycles
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FIELD OF THE INVENTION
This invention relates to novel nonpeptide substituted spiroheterobenzazepines useful as, for example, vasopressin receptor antagonists.
BACKGROUND OF THE INVENTION
Vasopressin is a nonapeptide hormone that is secreted primarily from the posterior pituitary gland. The hormone
Prodrug salts
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TECHNICAL FIELD
Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their
Prodrug salts
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TECHNICAL FIELD
Provided are novel prodrug salts of selective aquaporin inhibitors, e.g., of aquaporin-4 and/or aquaporin-2, of Formula I as described below, their use as pharmaceuticals and pharmaceutical compositions comprising them, and novel intermediates used in and novel processes for their
Benzamide derivatives and pharmaceutical composition comprising the same
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This invention relates to new benzamide derivatives and pharmaceutically acceptable salts thereof.
More particularly, it relates to new benzamide derivatives and pharmaceutically acceptable salts thereof which possess activities as vasopressin antagonistic activity, vasodilating activity,
Synthetic peptide amides
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FIELD OF THE INVENTION
The invention relates to synthetic peptide amides incorporating D-amino acids in the peptide chain and more particularly to such synthetic peptide amides that are kappa opioid receptor agonists, and methods for their use as prophylactic and therapeutic agents.
BACKGROUND
Kappa
Synthetic peptide amides
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FIELD OF THE INVENTION
The invention relates to synthetic peptide amides incorporating D-amino acids in the peptide chain and more particularly to such synthetic peptide amides that are kappa opioid receptor agonists, and methods for their use as prophylactic and therapeutic agents.
BACKGROUND
Kappa
Synthetic peptide amides
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FIELD OF THE INVENTION
The invention relates to synthetic peptide amides incorporating D-amino acids in the peptide chain and more particularly to such synthetic peptide amides that are kappa opioid receptor agonists, and methods for their use as prophylactic and therapeutic agents.
BACKGROUND
Kappa
Synthetic peptide amides
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FIELD OF THE INVENTION
The invention relates to synthetic peptide amides incorporating D-amino acids in the peptide chain and more particularly to such synthetic peptide amides that are kappa opioid receptor agonists, and methods for their use as prophylactic and therapeutic agents.
BACKGROUND
Kappa
Synthetic peptide amide dimers
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FIELD OF THE INVENTION
The invention relates to synthetic peptide amides incorporating D-amino acids in the peptide chain and more particularly to such synthetic peptide amides that are kappa opioid receptor agonists, and methods for their use as prophylactic and therapeutic agents.
BACKGROUND
Kappa
Synthetic peptide amides for pain
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FIELD OF THE INVENTION
The invention relates to synthetic peptide amides incorporating D-amino acids in the peptide chain and more particularly to such synthetic peptide amides that are kappa opioid receptor agonists, and methods for their use as prophylactic and therapeutic agents.
BACKGROUND
Kappa
Hapalindolinone compounds as vassopressin antagonists
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BACKGROUND OF THE INVENTION
This invention pertains to the field of vasopressin antagonists. Vasopressin (also known as Antidiuretic Hormone, ADH) is a pituitary peptide hormone that is vital for the maintenance of proper water balance in animals and man. The antidiuretic effect of vasopressin
Oxytocin and vasopressin antagonists
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BACKGROUND OF THE INVENTION
This invention pertains to the field of oxytocin and vasopressin antagonists.
In the field of obstetrics, one of the most important problems is the management of preterm labor. A significant number of the pregnancies progressing past 20 weeks of gestation experience
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