One non-invasive optode patch will be placed adjacent to the area of invasive monitoring and the second patch will be placed contralaterally. (12 hrs. daily is chosen primarily for budgetary reasons). The information for the non-invasive technology will be compared to the invasive technology.
ICG (Indocyanine Green) will be injected to derive absolute CBF and calibrate the DCS monitor to yield continuous absolute CBF. During each 12-hour monitoring session, for up to 14 days, the ICG will be injected at baseline(0.2 mg/kg,(4), every four hours (or less if signal is stable).

Traumatic Brain Injury

Ischemic Stroke

Intracerebral Hemorrhage

Subarachnoid Hemorrhage

Acute Anoxic Encephalopathy

ICG will be injected to derive absolute CBF and calibrate the DCS monitor to yield continuous absolute CBF. During each 12-hour monitoring session, for up to 14 days, the ICG will be injected at baseline(0.2 mg/kg,(4), every four hours (or less if signal is stable).

Indocyanine Green

University of Pennylvania Health System

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

Determine if the optical monitoring device's assessment of CBF is valid.

Determine if the optical monitoring system can detect an anaerobic adverse condition in the brain which might lead to neural injury.

Predict the later onset of a brain anaerobic condition.

No, study data only remains with the study team. update reports will be submitted to the NIH, however individual patient data will not be included.

intracranial hemorrhages/terminalia

Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor

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