justicia wynaadensis/hipersensitivitas

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A study of skin sensitivity to various allergens by skin prick test in patients of nasobronchial allergy.

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OBJECTIVE To study skin sensitivity to various allergens in patients of nasobronchial allergy. METHODS 2880 skin prick tests with 60 allergens were performed in 48 patients of nasobronchial allergy. RESULTS Most common offending allergens were insects (21.2%), followed by dusts (12.0%), pollens

Pharmacokinetics and in-situ absorption studies of a new anti-allergic compound 73/602 in rats.

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Compound 73/602 (AA) is a structural analogue of vasicinone, an alkaloid present in the leaves and roots of Adhatoda vasica (Acanthaceae). It possesses potent antiallergic activity in mice, rats and guinea pigs. The pK(a) of AA was determined to be 2.87+/-0. 19 by UV spectrophotometry. The

Justicia procumbens Extract (DW2008) Selectively Suppresses Th2 Cytokines in Splenocytes and Ameliorates Ovalbumin-Induced Airway Inflammation in a Mouse Model of Asthma.

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DW2008 is an anhydrous ethanol extract of Justicia procumbens produced by Dong-Wha Pharmaceutical, Inc., Co. as a candidate anti-asthmatic drug. In this study, DW2008 selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation by

Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues.

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Ambroxol is a widely used secretolytic agent originally developed from vasicine, a natural alkaloid found in Adhatoda vasica, extracts of which have been used to treat bronchitis, asthma, and rheumatism. We previously reported that ambroxol inhibits IgE-dependent mediator secretion from human mast

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