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Kahweol Reduces Food Intake of Caenorhabditis elegans
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The coffee diterpene kahweol may contribute to the anti-obesity effects of coffee, but its physiological effects have yet to be elucidated. Caenorhabditis elegans is used as an animal model in obesity research because its lipid metabolism is conserved in humans. The goal was to investigate
Kahweol Reduces Food Intake of Caenorhabditis elegans
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The coffee diterpene kahweol may contribute to the anti-obesity effects of coffee, but its physiological effects have yet to be elucidated. Caenorhabditis elegans is used as an animal model in obesity research because its lipid metabolism is conserved in humans. The goal was to investigate
Kahweol inhibits adipogenesis of 3T3-L1 adipocytes through downregulation of PPARγ.
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Kahweol, a compound from Coffea arabica, possesses antioxidant, anti-inflammatory, and antitumour properties. However, an anti-adipogenic effect has not yet been reported. In this study, we have shown that kahweol has an anti-adipogenic effect on 3T3-L1 adipocytes. Kahweol significantly inhibited
Kahweol Inhibits Lipid Accumulation and Induces Glucose-Uptake Through Activation of AMP-Activated Protein Kinase (AMPK).
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Weight loss ≥ 5 percent is sufficient to significantly reduce health risks for obese people; therefore, development of novel weight loss compounds with reduced toxicity is urgently required. After screening of natural compounds with antiadipogenesis properties in 3T3-L1 cells, we determined that
Mechanisms of action of coffee bioactive components on lipid metabolism.
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Coffee consumption is associated with reduced risk of metabolic syndrome, obesity and diabetes, which may be related to the effects of coffee and its bioactive components on lipid metabolism. Coffee contains caffeine, a known neuromodulator that acts as an adenosine receptor antagonist, as well as
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