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[Variation of cAMP in cerebral cortex and hippocampus in seizure mice induced by coriaria lactone].
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To study the relationship between cAMP and epilepsy, we investigated the effects of coriaria lactone (CL) on the levels of cAMP in cerebral cortex and hippocampus. Fifty normal WC1 mice were divided into 5 groups. All groups were injected with CL (2.5 mg/kg, i.m.), except the control group which was
[Effects of SC1001-sodium on hippocampal kindled seizures by coriaria lactone in rabbits].
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Healthy rabbits weighing 1.7-2.4 kg were used. According to Sawyer's atlas the stainless steel cannula and recording electrode were implanted into the left hippocampus of each animal. The kindling experiments were started one week after the surgical operation. For kindling, all animals received
[Effects of calcium channel blocker verapamil on hippocampal kindled seizures induced by coriaria lactone in rabbits].
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Eighteen fully kindled rabbits, whose epilepsy had been produced by intrahippocampal (i.h.) injections of 2 microliters of diluted solution containing 0.32 or 0.55 micrograms of coriaria lactone (CL), were separated into three groups. One of them was used as the control group. For seizure, all
[Study on red blood cell immune adherence function in coriaria lactone-induced epileptic seizure rats].
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The immune adherence function of red blood cells in 17 rats was studied. It was found that the rosette rate of red blood cell C3b receptor (RBC-C3bRR) was 7.45 +/- 1.36% in the epilepsy group (8 rats), and 10.84 +/- 1.77% in the control group (9 rats); and that the rosette rate of red blood cell
[Ultrastructural observation of SC1001-sodium on brain neurons kindled seizures by coriaria lactone in rabbits].
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The ultrastructural changes of hippocampus and cerebral cortex neurons were derived from the rabbits kindled by coriaria lactone and from the kindled rabbits after treatment with SC1001 Na. The results of experiment showed that the hippocampus and cerebral cortex neurons in the kindled group had
[Successive convulsion induced by coriaria lactone in 5-day-old rats].
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[An epileptic model of the generalized convulsion type of kindling induced by Coriaria lactone in rats].
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BCL-2 protein changes within the hippocampus cells in coriaria lactone-induced GTC seizure in rats.
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[Damage of experimental coriaria lactone convulsion on immature rat brain development and the protective effect of glucose].
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Effect of gamma-crotonolactone in experimental models of generalized absence seizures.
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The effect of the unsaturated lactone, gamma-crotonolactone (GCL), against spike wave discharges (SWD) in two pharmacological models of generalized absence seizures in rat was investigated. The models used were the gamma-hydroxybutyrate (GHB) model and the low dose pentylenetetrazole model. GCL
Evaluation of behavioral and pharmacological effects of Hedyosmum brasiliense and isolated sesquiterpene lactones in rodents.
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BACKGROUND
Hedyosmum brasiliense Miq. (Chloranthaceae) is an essential Brazilian species largely found in the Atlantic Forest. It is popularly known as "cidrão" and in folk medicine, this aromatic species is widely used as a calmative/tranquilizer and to treat sleep disorders.
OBJECTIVE
To examine
[Effect of SC1001-sodium on ADA activity of the thymus, spleen and brain in repeated seizure rats].
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Twenty nine adult SD rats in the experiment were randomly separated into two groups. Nineteen rats of them were intramuscularly injected (i.m.) with Coriaria lactone (CL, 2.5 mg/kg for female rat; 30 mg/kg for male rat) two days a time, continued 28 times, to induce repeated seizures, as the
Longitudinal ¹H MRS assessment of the thalamus in a Coriaria lactone-induced rhesus monkey status epilepticus model.
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Neurophysiological, biochemical and anatomical evidence implicates the thalamus as playing a role in epileptic seizures. Until recently, however, longitudinal characterization of in vivo thalamus dynamics had not been reported. In this study, we investigated the metabolism in the thalamus to
[Effect of coriaria lactone on the ATP-sensitive potassium channels in pyrimidal neurons of rats].
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OBJECTIVE
To acquire knowledge about the effect of Coriaria lactone (CL) on ATP-sensitive potassium channels (KATP) in cultured pyrimidal neurons of rats and the role of KATP in epileptogenesis.
METHODS
Experiments were conducted by the use of cell culture technique and single channel patch clamp
Influences of "spasmolytic powder" on pgp expression of Coriaria Lactone-kindling drug-resistant epileptic rat model.
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The earliest records of traditional Chinese medicine (TCM) prevention and treatment of epilepsy dated back to famous "Huang Di Nei Jing." TCM "spasmolytic powder" (equal-ratio compatibility of scorpion and centipede) is a famous prescription which was recognized as a useful add-on drug for
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