Addiction

Prevalence of New Psychoactive Substances Use

Prevalence of New Psychoactive Substances Use Among Outpatient of Addiction Management Clinic in Assiut University Hospital

All participant will subjected to the following:
Special sheet designed for the study in department of neurology and psychiatry at Assiut University hospital asking about spychoactive substance use regarding to type, amount, duration,cause of use, and cause for stoppage.
Addiction severity index Urinary drug screen

AAEsraa

Princible investigator

Assiut University

Patients in this arm will receive topical treatment with Minoxidil forte 5% gel three times per days for 4 weeks

Patients in this arm will receive topical treatment with glyceryl trinitrate 0.2% cream three times per days for 4 weeks

Anal Fissure

application of minoxidil forte 5% gel three time per day on the anus for four weeks

Minoxidil

application of glyceryl trinitrate 0.2% cream three time per day on the anus for four weeks

Glyceryl trinitrate

Mansoura university hospital

Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure

Topical 5% Minoxidil Versus 0.2%Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure: a Randomized Controlled Trial

the duration of time needed for complete healing defined as reepithelialization of the anoderm at the site of anal fissure

degree of relief of anal pain as measured by visual analogue scale (VAS) from 0 to 10 where 0 indicates no pain and 10 indicates the worst severe pain.

Sameh Emile

Lecturer of general surgery

Mansoura University

MOVANTIK™ (Naloxegol) 25 mg oral capsule, daily

Opioid-Induced Disorders

Esophagus Disorder

Naloxegol

Placebo Oral Capsule

Temple University

Movantik for Opioid-Related Esophageal Disorders

The effect of MOVANTIK™ (Naloxegol) on motor function, categorized as a 25% (mmHg) improvement in IRP (Integrated Relaxation Pressure) on high resolution esophageal manometry from baseline to visit three, comparing study group to placebo control group.

Mean change from baseline to visit three in subject esophageal symptom scores according to the PAGI-SYM.

Mean change from baseline to visit three in subject esophageal symptom scores according to the McGill pain inventory.

Mean change from baseline to visit three in subject esophageal symptom scores according to the GERD symptom check list.

Mean change from baseline to visit three in subject esophageal symptom scores according to the chest pain symptom questionnaire.

Mean change from baseline to visit three in subject esophageal symptom scores according to the daily diary

The occurrence of adverse events and early withdrawal in study group when compared to placebo control group to determine safety and tolerability.

laxative/sakit kepala

Prevalence of New Psychoactive Substances Use

Topical Minoxidil Versus Topical Glyceryl Trinitrate in Treatment of Chronic Anal Fissure

Movantik for Opioid-Related Esophageal Disorders

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