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malic acid/hypoxia
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The cardioprotective effects of citric Acid and L-malic Acid on myocardial ischemia/reperfusion injury.
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Organic acids in Chinese herbs, the long-neglected components, have been reported to possess antioxidant, anti-inflammatory, and antiplatelet aggregation activities; thus they may have potentially protective effect on ischemic heart disease. Therefore, this study aims to investigate the protective
Almitrine mimics hypoxic vasoconstriction in isolated rat lungs.
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The effect of almitrine bimesylate or the solvent malic acid on pulmonary vascular perfusion pressure was assessed in isolated rat lungs and on the contractile behavior of rat aorta and main pulmonary artery rings. Addition of almitrine to the lung perfusate during normoxia caused a dose-dependent,
Low-dose almitrine bismesylate enhances hypoxic pulmonary vasoconstriction in closed-chest dogs.
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The effect of almitrine bismesylate on the hypoxic pulmonary vasoconstrictor response was studied in six closed-chest dogs anesthetized with pentobarbital and paralyzed with pancuronium. The right lung was ventilated continuously with 100% O2; the left lung was ventilated either with 100% O2
Restored hypoxic pulmonary vasoconstriction by peripheral chemoreceptor agonists in dogs.
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Hypoxic stimulation of the peripheral chemoreceptors inhibits hypoxic pulmonary vasoconstriction (HPV). On the other hand, almitrine, a peripheral chemoreceptor agonist, has been reported in some studies to enhance HPV. To further explore this apparent contradiction, we investigated the effects of
Almitrine bismesylate reduces hypoxic pulmonary vasoconstriction in isolated rat lungs.
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The purpose of this study is to test how almitrine bismesylate (Alm) affects the function of pulmonary vasculature during normoxic ventilation, and whether low doses of Alm not causing detectable vasoconstriction during normoxic ventilation potentiate hypoxic pulmonary vasoconstriction (HPVC).
[Metabolomics study of the myocardial tissue of rats of cardiac blood stasis syndrome].
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OBJECTIVE
To find out the metabolite profile of rats' myocardial tissue of cardiac blood stasis syndrome (CBSS), and to analyze the metabolic pathway of CBSS rats' myocardial tissue by observing the changes of phenotypes intervened by Yangxin Tongmai Recipe (YTR).
METHODS
Acute myocardial infarction
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