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mastocytosis/diare
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Chronic intractable diarrhea caused by gastrointestinal mastocytosis.
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As mast cells have been highlighted in the pathogenesis of diarrhea-predominant irritable bowel syndrome, a new term "mastocytic enterocolitis" was suggested by Jakate and colleagues to describe an increase in mucosal mast cells in patients with chronic intractable diarrhea and favorable response to
Systemic mastocytosis: control of lifelong diarrhea by ingested disodium cromoglycate.
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A 16-year-old boy with systemic mastocytosis from birth had a lifelong history of pronounced diarrhea. Treatment with ingested disodium cromoglycate (DSCG) restored a normal bowel movement pattern and this has been maintained for the six months he has been on treatment. Changes in dosage have
Effect of cimetidine on gastric hypersecretion and diarrhea in systemic mastocytosis.
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Two patients had systemic mastocytosis and histamine excess, marked gastric acid and pepsin hypersecretion, and diarrhea. Cimetidine inhibited gastric acid secretion in both, but with only partial initial control of diarrhea. The other manifestations of mastocytosis were only partly controlled, even
Systemic Mastocytosis: A Rare Cause of Diarrhea
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Mastocytosis is a spectrum of neoplastic, clonal cell disorders that are characterized by mast cell hyperplasia and accumulation. Disease and clinical presentation can vary depending on the extent of spread, ranging from skin-limited cutaneous mastocytosis to systemic mastocytosis that can mimic
[Etiology of hepatosplenomegaly with concomitant diarrhea and vomiting? Systemic mastocytosis (malignant form)].
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Response to celecoxib in a patient with indolent systemic mastocytosis presenting with intractable diarrhea.
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Unusual hematologic malignancies. Case 1. Hematologic malignancy presenting with diarrhea and bony lesions: systemic mastocytosis.
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Use of interferon alpha-2b and prednisolone in the treatment of severe intractable diarrhea in a child with systemic mastocytosis.
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Secretory diarrhea and prostaglandin D2 overproduction in systemic mastocytosis.
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Systemic mastocytosis with portal hypertension. Autopsy findings and ultrastructural study of the liver.
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Systemic mastocytosis is a rare cause of portal hypertension with only two previously reported cases to our knowledge. A 51-year-old man who was seen with intractable diarrhea and abdominal distention was found to have this combination at autopsy. At autopsy the liver showed bridging portal
[Colonic involvement in systemic mastocytosis (author's transl)].
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The most common gastrointestinal lesions encountered in systemic mastocytosis are the gastric, duodenal and small bowell lesions. The authors present a case of diffuse colonic involvement diagnosed on a double contrast examination. The radiological signs correlated with the endoscopical and
Type Ib indolent mastocytosis with systemic involvement: cutaneous mastocytosis and gastrointestinal involvement at young girl.
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A 21-year-old young girl presents with intense abdominal pain, nausea, diarrhea in the context of a cutaneous eruption formed by erythematous and papulous elements with brown violet aspect, very pruriginous, occasioned by the preparation of some fishmeal. Similar eruption debuted from childhood from
Neurologic symptoms and diagnosis in adults with mast cell disease.
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OBJECTIVE
To identify complications of mastocytosis that impact the nervous system across a large cohort.
METHODS
In this retrospective series, we reviewed the electronic medical records of adult patients with a diagnosis of mastocytosis who were referred to a Neurologist at Mayo Clinic in
c-kit mutation and osteopetrosis-like osteopathy in a patient with systemic mast cell disease.
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We describe the case of a 69-year-old man with systemic mastocytosis and severe osteopetrosis who carries a somatic activating mutation in the c-kit proto-oncogene. The patient initially presented with urticaria pigmentosa, progressing to systemic mast cell disease with severe anemia due to bone
[Mastocytosis : Clinical aspects, diagnostics, therapy].
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Mastocytosis is a rare, almost exclusively sporadically occurring disease involving an increase in clonal tissue mast cells. The disease spectrum is heterogenous, ranging from isolated skin lesions with a normal life expectancy to rare, aggressive forms with very poor prognosis. Children are often
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