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Association of intensive morphine treatment and increased stroke incidence in prostate cancer patients: a population-based nested case–control study.
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OBJECTIVE
We address the potential problem of stroke induced by morphine exposure by comparing the incidence of stroke in cancer patients treated with and without morphine.
METHODS
We performed a population-based nested case–control retrospective analysis on the Longitudinal Health Insurance
Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
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Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alzheimer's and Parkinson's, ischemic stroke, epilepsy and other convulsive syndromes,
Adult responses to an ischemic stroke in a rat model of neonatal stress and morphine treatment.
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Critically ill newborn infants experience stressors that may alter brain development. Using a rodent model, we previously showed that neonatal stress, morphine, and stress plus morphine treatments each influence early gene expression and may impair neurodevelopment and learning behavior. We
Reversal by acupuncture of cardiovascular depression induced with morphine during halothane anaesthesia in dogs.
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The cardiovascular effects of morphine sulphate and/or acupuncture by means of electrocautery at Jen Chung (Go-26) were studied in 35 dogs. All animals were maintained under anaesthesia with halothane 0.75 per cent supplemented by the intravenous administration of succinylcholine to allow controlled
Pulmonary and systemic hemodynamic effects of delta9-tetrahydrocannabinol in conscious and morphine--chloralose-anesthetized dogs: anesthetic influence on drug action.
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Pulmonary and systemic hemodynamic effects of delta 9-tetrahydrocannabinol (delta 9-THC) in conscious dogs and in those anesthetized with morphine (3 mg/kg, i.m.) plus alpha-chloralose (100 mg/kg i.v.) were evaluated in this study. A decrease in the heart rate, cardiac output (PBF) and a concomitant
Cardiovascular response to the i.v. administration of morphine in critically ill patients undergoing IPPV.
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The haemodynamic changes following the administration of morphine 0.15 and 0.30 mg kg-1 i.v. were studied in 11 patients, free from known cardiac disease. All patients were acutely ill and their lungs were being ventilated mechanically. In those patients receiving 0.15 mg kg-1, the only haemodynamic
High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications.
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In rats with chronically implanted intrathecal catheters, high concentrations of morphine (3 microliters of 50 mg/ml: 150 micrograms) yielded a reliable and striking syndrome of pain behavior that involved intermittent bouts of biting and scratching at the dermatomes innervated by levels of the
The safety of morphine use in acute coronary syndrome: a meta-analysis.
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Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis.
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[Effect of high dosages of morphine and meperidine on haemodynamics, coronary blood flow and myocardial oxygen consumption in comparison to fentanyl and piritramide (author's transl)].
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Although morphine is one of the oldest drugs known to man, it has only recently been used in large doses as an anesthetic agent. The main advantage is the cardiovascular stability. The purpose of this investigation was to study the circulatory response to high equianalgesic doses of morphine and
Effects of halothane and morphine sulfate on myocardial compliance following total cardiopulmonary bypass.
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We evaluated the effect on diastolic myocardial compliance of halothane and morphine sulfate using 15 swine placed on total cardiopulmonary and right heart bypass with controlled aortic pressure, heart rate, and left ventricular preload. The animals were divided into three equal groups: (I) regional
Prebypass hemodynamic stability of sufentanil-O2, fentanyl-O2, and morphine-O2 anesthesia during cardiac surgery: a comparison of cardiovascular profiles.
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Cardiovascular responses and the need for intervention with vasoactive agents were measured prospectively in a randomized study of 50 adult patients receiving sufentanil (n = 20), fentanyl (n = 20), or morphine (n = 10) anesthesia for cardiac surgery. Measurements were recorded and compared during
Effects of naloxone and morphine on cerebral ischemia in gerbils.
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A therapeutic role for naloxone during stroke has been suggested, but a neurochemical site of action remains to be determined. Previous work with the gerbil cerebral cortex has shown that either bilateral secondary ischemia (60-min occlusion of the carotid arteries followed by 40-min reflow) or
Halothane and morphine-nitrous oxide anesthesia in patients undergoing coronary artery bypass operation. Patterns of intraoperative ischemia.
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To examine whether the hemodynamic responses to halothane or morphine-nitrous oxide anesthesia produce different patterns of myocardial ischemia in patients undergoing myocardial revascularization, we studied 26 patients anesthetized with nitrous oxide (50%) and either halothane (0.2% to 1.0%
Adrenergic response to morphine-diazepam anesthesia for myocardial revascularization.
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To evaluate sympathetic nervous system activity during narcotic-hypnotic "balanced anesthesia," plasma catecholamine concentrations and hemodynamic variables were assessed simultaneously in 10 men with coronary artery disease who received, sequentially, morphine sulfate, 3 mg/kg IV, and diazepam,
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