Anti-coronavirus obtained with double-filtration plasmapheresis (DFPP) from convalescent patients

Pneumonia, Viral

Corona Virus Infection

Antibodies obtained from consenting convalescent donors will be administered to ten consecutive patients who fulfill the inclusion criteria .

Anti-coronavirus antibodies (immunoglobulins) obtained with DFPP form convalescent patients

ASST - Papa Giovanni XXIII - Unit of Nephrology

Asst Hpg23 - Eas

ASST HPG23 - Intensive Care Unit

ASST HPG23 - Microbioly and Virology Unit

Sst Hpg23 - S.I.M.T.

IRFMN - Clinical Research Center for Rare Diseases

Convalescent Antibodies Infusion in COVID 19 Patients

A Pilot Study to Explore the Efficacy and Safety of Rescue Therapy With Antibodies From Convalescent Patients Obtained With Double-filtration Plasmapheresis (DFPP) and Infused in Patients With Coronavirus Disease 2019 (COVID-19) and Need of Oxygen Support Without Mechanical Ventilation

Marker of complement activation in plasma.

Piero Luigi Ruggenenti

Director, Unit of Nephrology

Aferetica

The patients in this arm will receive TPE

The patients will receive the standard of care for septic shock treatment

Septic Shock

The removed plasma is 'exchanged or replaced' with either IV fluids, albumin, and/or Fresh frozen plasma

Therapeutic plasma exchange

Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis

PILOT STUDY in the Use of Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis

Proportion of patients who experience at least 1 Adverse Event (AE)

Proportion of patients who discontinue TPE administration due to an AE

3. Enrollment rate (patients screened, patients eligible, patients approached, patients enrolled)

Protocol completion (patients who complete study protocol)

Resolution or worsening of organ dysfunction as per SOFA score

Days in ICU (censored to day ready for discharge)

Once the results have been analyzed and published the de-identified data will be made available to other researchers

Dr. George Alvarez

Intensivist, Department of Critical Care Medicine

Alberta Health Services, Calgary

Consecutive Adults patients with vasoplegic septic shock with at least 2 organ dysfunction will receive TPE

Semiselective immunoadsorption (GAM peptide adsorber)

Semiselective immunoadsorption (GAM peptide adsorber) in combination with membrane filtration

Immunology

Membrane filtration

Semiselective IA

Medical University of Vienna

ABO Blood Group Antibody Elimination by a Combination of Semiselective Immunoadsorption Therapy and Membrane Filtration

Farsad Eskandary

Fresenius Medical Care Deutschland GmbH

At first visit, patients will be randomized by blocked randomization into 2 sides of scalp. Experimental side will be injected with botulinum toxin A ( Botox) 2 units per 6.05 cm2 of lesion ( Concentration 2 units of Botox per 0.1 ml of normal saline ).

At visit0, patients will be injection with triamcinolone acetonide concentration at 10 mg/ml on the comparison side

Alopecia Areata

Using concentration at 2 units per 0.1 of dilution with normal saline Injection in the first visit and follow up at 1 week, 1,2,3 and 4 months after injection

Botulinum toxin type A

Using concentration at 10 mg/ml and equal amount of botulinum toxin A dilution

myasthenia gravis/albumin

Convalescent Antibodies Infusion in COVID 19 Patients

Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis

ABO Blood Group Antibody Elimination by a Combination of Semiselective Immunoadsorption Therapy and Membrane Filtration

The Comparison Study of Intralesional Botulinum Toxin A and Corticosteroid Injection for Alopecia Areata

Randomized Study of Intravenous Immunoglobulin in Patients With Mild or Moderate Myasthenia Gravis

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