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neoplasms/phosphatase
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Protein tyrosine phosphatase mutations in cancers
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This application incorporates a 502 KB text file named "seqlst00631" created Jul. 22, 2010, which is the sequence listing for this application.
TECHNICAL FIELD OF THE INVENTION
This invention is related to the area of cancer. In particular, it relates to diagnosis, prognosis, treatment, drug
Protein tyrosine phosphatase mutations in cancers
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TECHNICAL FIELD OF THE INVENTION
This invention is related to the area of cancer. In particular, it relates to diagnosis, prognosis, treatment, drug discovery, target discovery, clinical testing for cancer.
BACKGROUND OF THE INVENTION
Phosphorylation of tyrosine residues is a central feature of most
Methods for identifying a tyrosine phosphatase abnormality associated with neoplastic disease
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BACKGROUND OF THE INVENTION
Protein tyrosyl phosphorylation is an important cellular regulatory mechanism. Much work has implicated protein tyrosine kinases (PTKs) in the control of cell proliferation and differentiation. Many PTKs, when mutated and/or captured by retroviruses, can promote
Alkaline phosphatase compositions to reduce skin cancer
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FIELD OF THE INVENTION
This invention relates to the use of human alkaline phosphatase, such as placental alkaline phosphatase or transferrin alone or alkaline phosphatase in combination with transferrin, and, optionally, .alpha..sub.1-antitrypsin to prevent or reduce the growth of skin cancer in
Use of protein tyrosine phosphatase zeta as a biomolecular target in the treatment and visualization of brain tumors
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FIELD OF USE
The present invention relates to the use of proteins which are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of
Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Sep. 18, 2010, is named 26228PCT.txt and is 100,737 bytes in size.
FIELD OF THE
Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
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FIELD
The disclosure provides methods for characterizing a prostate cancer sample by detecting changes in expression of ERG and/or PTEN which are shown herein to be correlated with prostate cancer capsular penetration, biochemical recurrence, and more aggressive forms of prostate cancer. Also
Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
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FIELD
The disclosure provides methods for characterizing a prostate cancer sample by detecting changes in expression of ERG and/or PTEN which are shown herein to be correlated with prostate cancer capsular penetration, biochemical recurrence, and more aggressive forms of prostate cancer. Also
Maleiimide anti-tumor phosphatase inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention provides maleiimide compounds and pharmaceutical compositions comprising same. The present invention further provides methods of regulating protein phosphorylation and dephosphorylation by phosphatases inhibition and methods
Therapeutic and diagnostic applications of prostatic acid phosphatase in prostate cancer
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FIELD OF THE INVENTION
This invention relates to the fields of prostate cancer diagnosis and treatment.
BACKGROUND OF THE INVENTION
Various scientific and scholarly articles are referred to in brackets throughout the specification.
These articles are incorporated by reference herein to describe the
Method of treatment of breast cancers over-expressing the SHP2 signature genes
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FIELD OF THE INVENTION
The present invention relates to methods for treating cancer.
BACKGROUND OF THE INVENTION
Each year 1.1 million new cases of breast cancer occur among women worldwide and 400,000 women will die from this disease (www.uicc.org, www.who.int). Although progress has been made in
Protein kinase and phosphatase inhibitors
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INCORPORATION OF SEQUENCE LISTING
The contents of the text file named "28856-502C02US_ST25.txt", which was created on Sep. 22, 2010 and is 3 KB in size, are hereby incorporated by reference in their entirety.
BACKGROUND OF THE INVENTION
Protein kinases are a large class of enzymes which catalyze the
Protein kinase and phosphatase inhibitors and methods for designing them
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BACKGROUND OF THE INVENTION
Protein kinases are a large class of enzymes which catalyze the transfer of the .gamma.-phosphate from ATP to the hydroxyl group on the side chain of Ser/Thr or Tyr in proteins and peptides and are intimately involved in the control of various important cell functions,
PTPN11 (SHP-2) mutations and cancer
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FIELD OF THE INVENTION
The present invention relates to methods of diagnosing and treating certain types of cancer and pre-cancerous conditions, including those deriving from hematopoietic cells such as myeloid cells and lymphoid cells. In particular, the invention pertains to diagnostic and
Phosphatase associated with metastasis
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to the field of cancer diagnostics and therapeutics. In particular it relates to a gene which appears to be significantly associated with the progression of cancer to more advanced stages, including metastasis.
2. Background
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