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Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
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FIELD
This application relates to novel variant proaerolysin (PA) proteins and methods of their use to treat localized and metastatic prostate cancer.
BACKGROUND
One of every three cancers diagnosed in American males is of prostatic origin, making prostate cancer the most commonly diagnosed
Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
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FIELD
This application relates to novel variant proaerolysin (PA) proteins and methods of their use to treat localized and metastatic prostate cancer.
BACKGROUND
One of every three cancers diagnosed in American males is of prostatic origin, making prostate cancer the most commonly diagnosed
Proaerolysin containing protease activation sequences and methods of use for treatment of prostate cancer
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FIELD
This application relates to novel variant proaerolysin (PA) proteins and methods of their use to treat localized and metastatic prostate cancer.
BACKGROUND
One of every three cancers diagnosed in American males is of prostatic origin, making prostate cancer the most commonly diagnosed
Serine proteases as biomarkers for ovarian cancer
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FIELD OF THE INVENTION
The described invention generally relates to ovarian cancer.
BACKGROUND
Ovarian Cancer
Ovarian cancer ranks as the fifth most common cancer in women and has the highest mortality rate among gynecologic malignancies (Suh K S, Park S W, Castro A, Patel H, Blake P, Liang M, et
Anti-tumor protease preparations
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to an anti-tumor agent containing protease originating from microorganisms as an effective component, to an anti-tumor agent containing chemically modified protease originating from microorganisms as an effective component,
Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents
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BACKGROUND OF THE INVENTION
1. Field of Invention
This invention relates to serine protease inhibitor Kazal (SPIK/SPINK/PSTI) and more specifically, its inhibitors and the use of inhibitors of SPIK as anti-cancer agents and anti-viral agents such as hepatitis B and C virus (HBV and HCV).
2.
Personalized protease assay to measure protease activity in neoplasms
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FIELD OF THE INVENTION
This invention pertains to methods and composition that find use in diagnostic, prognostic and characterization of neoplasia samples based on the ability of a neoplasia sample to cleave a MTS molecule of the present invention.
BACKGROUND OF THE INVENTION
Introduction
Cell
Nucleic acids that encode testes specific protease and detect DNA hypomethylated in cancer cells
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FIELD OF THE INVENTION
The present invention provides Methyl- (or Mutant-) Differential Display (MDD) methods and nucleic acid probes for detecting mutations and/or the methylation patterns of nucleic acids. Genes are frequently not methylated in the cells where they are expressed but are methylated
Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates generally to the prostate and specifically to a novel complex of hK2 and PI-6 formed in the prostate, and methods of using the novel complex.
2. Description of the Prior Art
Throughout this application, various references
Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex and its constituents
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates generally to the prostate and specifically to a novel complex of hK2 and PI-6 formed in the prostate, and methods of using the novel complex and its constituents.
2. Description of the Prior Art
Throughout this application,
Protease K resistant arginine deiminase, its method of preparation and its use as an anti-neoplastic agent
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FIELD OF THE INVENTION
The invention relates to an enzyme, arginine deiminase. In particular, it relates to a unique arginine deiminase isolated from mycoplasmas. More particularly, the invention is directed to a mycoplasmal proteinase K resistant arginine deiminase and to a method of preparing
Ricin-like toxin variants for treatment of cancer, viral or parasitic infections
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FIELD OF THE INVENTION
The invention relates to proteins useful as therapeutics against cancer, viral infections, parasitic and fungal infections. The proteins contain A and B chains of a ricin-like toxin linked by a linker sequence that is specifically cleaved and activated by proteases specific to
Compositions and methods for inhibition of cancer invasion and angiogenesis
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FIELD OF THE INVENTION
The present invention relates generally to the field of medicine, and relates specifically to angiogenesis and metastasis of cancer tissues. Specifically the invention relates to the use of antagonists of the serine integral membrane protease, dipeptidyl peptidase IV (DPPIV
Cancer cell migration and cancer cell invasion inhibitor
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TECHNICAL FIELD
The present invention relates to cancer cell migration and cancer cell invasion inhibitors. More specifically, the present invention relates to a PAR1 antibody inhibiting a cell migration activity and a cell invasion activity induced by MMP1 as well as a medicinal composition
Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same
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CROSS REFERENCE TO RELATED APPLICATION
This application is a National Stage of International Application No. PCT/KR2011/009914 filed Dec. 21, 2011, claiming priority based on Korean Patent Application No. 10-2010-0132955 filed Dec. 23, 2010, the contents of all of which are incorporated herein by
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