The PS128, which belongs to Lactobacillus plantarum subsp. plantarum, 2 caps daily use.

The PS23 belongs to Lactobacillus paracasei group, 2 caps daily use.

The placebo capsule contains microcrystalline cellulose, 2 caps daily use.

Probiotics

PS128 belongs to Lactobacillus plantarum subsp. plantarumand. Probiotic capsules contain 10 billion CFU (colony forming units) of PS128

PS128

PS23 belongs to Lactobacillus paracasei group.Probiotic capsules contain 10 billion CFU (colony forming units) of PS23

PS23 live

The PS23 heat-treated probiotic capsule contain 10 billion of PS23 cells.

PS23 heat-treated

The placebo capsule contains microcrystalline cellulose.

Placebo

Mackay Memorial Hospital

Psychiatric Symptoms in Employees Experiencing High Levels of Stress Before and After the Intake of Probiotics

Associations of Serum Total Antioxidant Capacity and Sleep or Psychiatric Symptoms in Employees Experiencing High Levels of Stress Before and After the Intake of Probiotics

The PSS scores is a rating tool used to gauge the course of stree. The minimum total score possible is 0 and the maximum total score possible is 40. Higher values represent a worse outcome.

The job stress scale from Ministry of Labor is a rating tool used to gauge of stress.

The ISI is a rating tool used to gauge of sleeping. Higher values represent a worse outcome.

The State-Trait Anxiety Inventory (STAI) is a commonly used measure of trait and state anxiety. All items are rated on a 4-point scale (e.g., from "Almost Never" to "Almost Always"). Higher scores indicate greater anxiety.

The Profile of Mood States (POMS) is a psychological rating scale used to assess transient, distinct mood states.

TAC is the biomarker for Oxidative stress

DHEA-S (Dehydroepiandrosterone sulfate) is the biomarker for anti-aging，among the neuroactive steroids, dehydroepiandrosterone (3b-hydroxyandrost-5-ene-17-one, [DHEA]) and its sulfated metabolite DHEA sulfate (DHEAS) have been shown to be potent modulators of neural function, including neurogenesis, neuronal growth and differentiation, and neuroprotection. Highlighting the potential health significance of DHEA and DHEAS in humans, serum concentrations decrease steadily with age, with lowest concentrations present at the time many diseases of aging and neurodegeneration become apparent.

Cortisol is a steroid hormone that is produced by the adrenal glands which sit on top of each kidney. When released into the bloodstream, cortisol can act on many different parts of the body and can help:
body respond to stress or danger increase your body's metabolism of glucose control your blood pressure reduce inflammation. Cortisol is also needed for the fight or flight response which is a healthy, natural response to perceived threats. The amount of cortisol produced is highly regulated by your body to ensure the balance is correct.

High-sensitivity C-reactive protein (hsCRP) is a marker of inflammation that predicts incident myocardial infarction, stroke, peripheral arterial disease, and sudden cardiac death among healthy individuals with no history of cardiovascular disease, and recurrent events and death in patients with acute or stable coronary syndromes.

Salivary alpha-amylase activity (sAA) is often considered to be surrogate markers of sympathetic activation in response to stress.

Secretory IgA in saliva stands in a negative correlation to the level of the experienced stress

lactoferrin's multiple activities lie in its capacity to bind iron and to interact with the molecular and cellular components of hosts and pathogens. it can bind and sequester lipopolysaccharides, thus preventing pro-inflammatory pathway activation, sepsis and tissue damages.

Lysozyme plays a pivotal role in the prevention of bacterial infections by attacking peptidoglycan in the bacterial cell wall.

Shu-I Wu

Senior Attending Physician

Bened Biomedical Co., Ltd.

Parkinson Disease

Inflammation

Rifaximin 550 MG, TWICE A DAY, FOR 7 DAYS

Rifaximin 550 MG

Shuang Ho Hospital

Modulation of Gut Microbiota by Rifaximin in PD Patients

Comparing the gut microbiota analyzed by 16sRNA with baseline

Comparing the blood level of inflammatory/infection markers (TNF-alpha, IL-6, LPS & zonulin) and exosomal alpha-synuclein

Chien Tai Hong

Doctor, Assisstant Professor, Principal Investigator

Taipei Medical University Shuang Ho Hospital

People at early stage of Parkinson's disease

Zinc sulfate 10 mg in children younger than 1 year old, 20 mg in children older than 1 year old

Pneumonia

Children, Only

Zinc sulfate 10 mg for children younger than 1 year old, 20 mg for children older than 1 year old, will be diluted in 1 ml of sterile water and administered orally every day in the morning during hospitalization

Zinc sulfate

The placebo group will receive glucose diluted in 1 ml of sterile water orally every day during hospitalization

Glucose

Hospital Pediatrico de Coyoacan

Hospital General de Mexico

Immunomodulation by Zinc Supplementation in Children With Pneumonia

Assessment of the Immunomodulatory Effect of Zinc Supplementation on the Clinical Evolution of Children With Pneumonia

Hours since the admission to the hospital to disappear the respiratory distress

Hours since the admission to the hospital to normalize the oxygen saturation

Hours since the admission to the hospital to have improvement in clinical symptoms

Hours to have normal temperature since the admission to the hospital

Th1 cytokines (interferon gamma, IL-2, tumor necrosis factor alfa) and Th2 cytokines (IL-4, IL-10, IL-6) will be determined in blood samples in 2 times: at the admission of the patient and at the discharge

Blood draws will be taken at the hospital admission and at the discharge of the patient to measure the lymphoproliferative capacity of their lymphocytes by flow cytometry

Rosa Maria Wong Chew

Professor B. Head of the Infectious Diseases Research Laboratory

Universidad Nacional Autonoma de Mexico

After an 8-10 hour overnight fast, Group A will receive two soft capsules of TPGS (400mg) emulsified berberine. Following a 7 day wash out period, Group A participants will then receive four capsules of the Quillaja extract emulsified berberine (200mg). Following another 7 day wash out period, Group A participants will then receive two hard shell capsules of the berberine reference powder 400mg. Each TPGS and berberine reference powder capsules contains 400 mg berberine. Each Quillaja extract capsule contains 200 mg berberine. The total amount of berberine throughout is 800 mg.

After an 8-10 hour overnight fast, Group B will receive four soft capsules of Quillaja extract emulsified berberine (400mg). Following a 7 day wash out period, Group B participants will then receive two hard shell capsules of the berberine reference powder (400mg). Following another 7 day wash out period, Group B participants will then receive two soft gel capsules of TPGS emulsified berberine (400mg). Each TPGS and berberine reference powder capsules contains 400 mg berberine. Each Quillaja extract capsule contains 200mg berberine. The total amount of berberine throughout is 800 mg.

After an 8-10 hour overnight fast, Group C will receive two hard shell capsules of the berberine reference powder (400mg). Following a 7 day wash out period, Group C participants will then receive two soft gel capsules of TPGS emulsified berberine (400mg). Following another 7 day wash out period, Group C participants will then receive four capsules of the Quillaja extract emulsified berberine (200mg). Each TPGS and berberine reference powder capsules contains 400 mg berberine. Each Quillaja extract capsule contains 200mg berberine. The total amount of berberine throughout is 800 mg.

Healthy

Two capsules of berberine. Each capsule contains 400 mg berberine. The total amount of berberine throughout is 800 mg.

Berberine

Two capsules of TPGS/Quillaja extract emulsified berberine. Each capsule contains 400 mg berberine. The total amount of berberine throughout is 800 mg.

TPGS emulsified berberine

Four capsules of Quillaja extract emulsified berberine. Each capsule contains 200 mg berberine. The total amount of berberine throughout is 800 mg.

Quillaja extract emulsified berberine

Food Science and human nutrition department at University of Florida

The Absorption of Bioactive Berberine in Human

To Test the Efficacy of Novel Berberine Emulsification by TPGS or Quillaja Extract on the Absorption of Berberine Compared to Berberine Powder in Humans

To determine change in bioavailability of orally ingested berberine in human volunteers by increasing the area under the concentration-time curve (AUC).

To determine change in bioavailability of orally ingested berberine in human volunteers by increasing its plasma concentration peak concentration (Cmax).

To determine change in bioavailability of orally ingested berberine in human volunteers by increasing its the time point of maximum plasma concentration (Tmax).

neurodegenerative diseases/diare

Psychiatric Symptoms in Employees Experiencing High Levels of Stress Before and After the Intake of Probiotics

Modulation of Gut Microbiota by Rifaximin in PD Patients

Immunomodulation by Zinc Supplementation in Children With Pneumonia

The Absorption of Bioactive Berberine in Human

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