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neurodegenerative diseases/seizures
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Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration
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BACKGROUND
1. Field of the Invention
This invention relates to analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic and anti-necrotic neuroprotective, to methods of making them, to
Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases
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FIELD OF THE INVENTION
This invention is related to branched chain amino acid-dependent amino transferase (BCAT) inhibitors. The invention is also directed to the use of BCAT inhibitors as neuro-protective agents for treating conditions such as stroke, cerebral ischemia, central nervous system
Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases
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FIELD OF THE INVENTION
This invention is related to branched chain amino acid-dependent amino transferase (BCAT) inhibitors. The invention is also directed to the use of BCAT inhibitors as neuro-protective agents for treating conditions such as stroke, cerebral ischemia, central nervous system
Compositions and methods for treating neurological diseases or injury
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BACKGROUND OF THE INVENTION
Pursuant to 37 C.F.R. 1.821(c), a sequence listing is submitted herewith as an ASCII compliant text file named "MESCP0071USC1_ST25.txt", created on Dec. 5, 2017 and having a size of .about.3 kilobytes. The content of the aforementioned file is hereby incorporated by
Compositions and methods for treating neurological diseases or injury
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The sequence listing that is contained in the file named "MESCP0071US_ST25.txt", which is 3 KB (as measured in Microsoft Windows.RTM.) and was created on Apr. 30, 2015, is filed herewith by electronic submission and is incorporated by reference herein.
BACKGROUND OF THE INVENTION
1. Field of the
Substituted 2,3-benzodiazepin-4-ones and the use thereof
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This application claims benefit of U.S. provisional application Ser. No. 60/013,813 filed Mar. 21, 1996.
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is in the field of medicinal chemistry. In particular, the invention relates to novel substituted 2,3-benzodiazepin-4-ones.
Methods of using GDNF as a neuroprotective agent
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FIELD OF THE INVENTION
The present invention relates to the use of glial-derived neurotrophic factor (GDNF) as a neuroprotective agent, and more particularly as an anti-seizure therapeutic.
BACKGROUND OF THE INVENTION
Epilepsy is a common neurodegenerative disorder. Children and teens have the
Nutritional methods utilizing compositions containing RNA, CA.sup.+2, Mg.sup.+2 and/or ascorbate
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to a nutritional agent which promotes recovery from conditions of cerebrospinal degenerative diseases, such as epilepsy, an attach of convulsion, brain degenerative disease, cranial nerve disease, cerebral basal ganglion
Method of treating, preventing or inhibiting central nervous system injuries and diseases
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a method of treating, preventing or inhibiting central nervous system (CNS) injuries and diseases. In particular, the invention relates to a method of treating, preventing or inhibiting a CNS injury or disease in a
4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs, as well as novel intermediates of the 4-substituted analogs. The analogs are selectively active as antagonists of
4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs, as well as novel intermediates of the 4-substituted analogs. The analogs are selectively active as antagonists of
2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as
2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 2-substituted piperidine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also directed to the use of 2-substituted piperidine analogs as
4-substituted piperidine analogs and their use as subtype selective NMDA receptor antagonists
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is related to 4-substituted piperidine analogs, including hydroxypiperidine and tetrahydropyridine analogs. The analogs are selectively active as antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes. The invention is also
Piperidine derivatives as subtype selective N-Methyl-D-Aspartate antagonists
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FIELD OF INVENTION
The invention relates to piperidine derivatives as N-Methyl-D-Aspartate (NMDA) antagonists useful in the treatment of diseases and disorders responsive to antagonism of NMDA receptors.
BACKGROUND OF THE INVENTION
Many of the physiological and pathophysiological effects of the
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