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nucleotidase/atrofi
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[Early changes in retinal 5'-nucleotidase activity in hereditary retinal degeneration].
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Activity of soluble cGMP phosphodiesterase (PDE) and of two membrane enzymes, 5'-nucleotidase and Na,K-ATPase, was studied in the developing retina of rats with inherited retinal degeneration. It was found that by day 10 of life, the content of 5'-nucleotidase in the afflicted rats was significantly
[Changes of enzymatic activity in the spinal cord of guinea pigs during wallerian degeneration; acid and alkaline phosphatases, 5-nucleotidases and ATPases].
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[Modifications of enzymatic activity of spinal cord in guinea pigs in wallerian degeneration (acid and alkaline phosphatase, 5-nucleotidase and ATPASE). II. Biochemical evaluation and statistical evaluation of the results].
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Histochemical demonstration of 5'-nucleotidase activity in inflammatory muscle disease.
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Using a histochemical method, 5'-nucleotidase activity was investigated in 80 muscle biopsy specimens, including specimens from eight patients with muscular dystrophy, 18 with nonspecific type II fiber atrophy, 15 with polymyositis, and 29 histologically normal controls. An interstitial reaction for
Synaptic 5'-nucleotidase activity reflects lesion-induced sprouting within the adult rat dentate gyrus.
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In development, the ectoenzyme 5'-nucleotidase marks maturing cerebellar and cortical synapses, but it is localized in glial cells in the normal, adult nervous system. With a histochemical lead technique, we have now investigated its localization during reactive synaptogenesis in the dentate gyrus
5'-Nucleotidase of cerebellar molecular layer: reduction in Purkinje cell-deficient mutant mice.
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The molecular layer of the cerebellar cortex contains high levels of the enzyme 5'-nucleotidase (EC 3.1.3.5), localized predominantly to Bergmann glia. In the present study, histochemical methods have been employed to examine the distribution of cerebellar 5'-nucleotidase in mice of two separate
Cytochemistry of 5'-nucleotidase in the superior cervical ganglion of the rat: effects of pre- and postganglionic axotomy.
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5'-Nucleotidase, a prominent nucleoside-producing ectoenzyme of glial plasma membranes, was studied by enzyme cytochemistry in the superior cervical ganglion of the rat under normal conditions and after pre- and postganglionic axotomy. In normal ganglia 5'-nucleotidase was restricted to capillary
5'-nucleotidase activity in the spinning gland cells of Diacrisis obliqua (Arctiidae: Lepidoptera).
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5'-nucleotidase activity in the spinning gland cells of an Indian moth, Diacrisia obliqua has been studied for the first time during prefunctional, functional and postfunctional phases of development. The enzyme seems to play an active role in the metabolism of silk secretion. Differential
Increased Ap4A levels and ecto-nucleotidase activity in glaucomatous mice retina.
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The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of degradation machinery through ecto-nucleotidase activity
Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.
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The retina-specific human ABC transporter (ABCR) functions in the retinal transport system and has been implicated in several inherited visual diseases, including Stargardt disease, fundus flavimaculatus, cone-rod dystrophy, and age-related macular degeneration. We have previously described a
Degenerating exo-erythrocytic forms of Plasmodium berghei in rat liver: an ultrastructural and cytochemical study.
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Morphological and cytochemical aspects of the host response to almost mature exo-erythrocytic forms (EEF) of Plasmodium berghei in rat hepatocytes were studied by electron microscopy. Young stages (less than 47 h) never evoked a local reaction. Two types of nearly mature EEF (47-51 h) could be
Cadmium induces osteomalacia mediated by proximal tubular atrophy and disturbances of phosphate reabsorption. A study of 11 autopsies.
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Osteomalacia of cadmium (Cd) poisoning (Itai-Itai disease) is induced by renal tubular dysfunction; however, the precise pathological changes and mechanisms have not been adequately elucidated. Of the 25 inhabitants in a Cd-polluted area who developed chronic tubular proteinuria, 22 individuals died
5'-Nucleotidase in Dictyostelium: protein purification, cloning, and developmental expression.
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5'-Nucleotidase (5NU) in Dictyostelium discoideum is an enzyme that shows high substrate specificity to 5'-AMP. The enzyme has received considerable attention in the past because of the critical role played by cyclic AMP in cell differentiation in this organism. Degradation of cAMP by cAMP
Peyer's patches in experimental Salmonella dublin infection in calves. Microvascular and epithelial changes contributing to atrophy of lymphoid follicles.
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Six calves were infected per os with Salmonella dublin and killed nine hours to seven days later. Early changes included occlusion of capillaries with a hyaline material, particularly in the ileal Peyer's patch (PP). Central areas of the follicles contained hemorrhages and edema. In later stages the
Ornithodoros savignyi: soft tick apyrase belongs to the 5'-nucleotidase family.
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Salivary apyrases are nucleotide-metabolising enzymes that blood-feeding parasites utilise for modulation of extracellular nucleotides to prevent platelet activation and aggregation. In this study a 5'-nucleotidase specific degenerate primer was used to identify homologous transcripts from
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