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Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation
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This is the national stage of International Application PCT/HU2014/000127, filed Dec. 18, 2014.
TECHNICAL FILED OF THE INVENTION
The present invention is based on potent analgesic (anti-hyperalgesic) effect of semicarbazide-sensitive amine oxidase (SSAO) also known as vascular adhesion protein 1
Method of inhibiting NADPH oxidase
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BACKGROUND OF THE INVENTION
The present invention relates to methods for treating inflammatory disorders. More specifically, the present invention concerns the control of the generation of free radicals in the immune response.
Phagocytic leukocytes are an important part of the body's defense against
Method of inhibiting NADPH oxidase
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BACKGROUND OF THE INVENTION
The present invention relates to methods for treating inflammatory disorders. More specifically, the present invention concerns the control of the generation of free radicals in the immune response.
Phagocytic leukocytes are an important part of the body's defense against
Acetylenic compounds useful in treating inflammatory disorders
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
The research and development of the invention described below was not federally sponsored.
BACKGROUND OF THE INVENTION
This invention relates to a series of acetylenic compounds, pharmaceutical compositions and methods for use thereof.
Substituted heteroaryl and heterocyclic compounds useful in treating inflammatory disorders
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FIELD OF THE INVENTION
This invention relates to a series of substituted heteroaryl and heterocyclic compounds, pharmaceutical compositions and methods for use thereof in treating or ameliorating an inflammatory disorder. More particularly, the substituted heteroaryl and heterocyclic compounds of
Treatment of auto-immune and inflammatory diseases
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This invention relates to the treatment of autoimmune and inflammatory diseases such as rheumatoid arthritis, lymphadenopathies, hemolytic anemias, purpura, ankylosing spondylitis, multiple sclerosis, diabetes mellitus, and various disorders of reproduction.
Defects in the biosynthesis and
Treatment of auto-immune and inflammatory diseases
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This invention relates to the treatment of auto-immune and inflammatory diseases such as rheumatoid arthritis, lymphadenopathies, hemolytic anemias, purpura, ankylosing spondylitis, multiple sclerosis, diabetes mellitus, and various disorders of reproduction.
Defects in the biosynthesis and
Alkaloid compounds for treating depression, substance addictions, and indications associated with chronic inflammation
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BACKGROUND
Monoamine oxidase (MAO) inhibitors can regulate the level of monoamines and their neurotransmitter release in different brain regions and in the body (including dopamine, norepinephrine, and serotonin). MAO inhibitors (MAOI) can thereby affect the modulation of neuroendocrine function,
Methods related to the treatment of neurodegenerative and inflammatory conditions
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FIELD OF THE INVENTION
The invention relates to methods of affecting various biological mechanisms related to inflammation, the resultant inflammation and the disorders that may be caused thereby. More specifically, the invention relates to administration of compounds for neuroprotective and/or
Methods related to the treatment of neurodegenerative and inflammatory conditions
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FIELD OF THE INVENTION
The invention relates to methods of affecting various biological mechanisms related to inflammation, the resultant inflammation and the disorders that may be caused thereby. More specifically, the invention relates to administration of compounds for neuroprotective and/or
Methods related to the treatment of neurodegenerative and inflammatory conditions
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SEQUENCE LISTING
The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Feb. 10, 2012, is named 84553CON.txt and is 6,023 bytes in size.
FIELD OF THE INVENTION
The
Compounds for inhibiting semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1) and uses thereof for treatment and prevention of diseases
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This is the National Stage of International Application PCT/HU2009/000082, filed Sep. 11, 2009.
FIELD OF THE INVENTION
The present invention relates to a compound having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting
Carbocyclic hydrazino inhibitors of copper-containing amine oxidases
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is in the field of medicinal chemistry and is directed to carbocyclic hydrazino compounds and their use as inhibitors of copper-containing amine oxidases (E.C. 1.4.3.6) and enzymes of significant identity thereto. The
Inhibitors of copper-containing amine oxidases
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is in the field of medicinal chemistry and is directed to hydrazino compounds and their use as inhibitors of copper-containing amine oxidases (E.C. 1.4.3.6) and enzymes of significant identity thereto. The compounds of the
Methods for ameliorating and preventing central nervous system inflammation
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TECHNICAL FIELD
This invention relates to molecular and cellular biology, biochemistry and medicine. The invention provides compositions and methods for ameliorating or preventing pathologies or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, interleukin-6
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