The study comprises one arm of 12 healthy Jamaican male and female adults with normal body mass inex, aged 20 to 45 years, receiving a test meal containing the common bean that was intrinsically labelled with deuterium .

Nutrition Deficiency Due to A Particular Kind of Food

The intervention comprises a test meal of intrinsically deuterium labelled stewed common bean with rice. The meal is mixed with a reference protein (Universally labelled 13C-spirulina, 12 mg/kg) and 13C6-Phenylalanine (0.05mg/kg) which is divided into equal mini meals and fed hourly over 8 hours. Protein in the total meal provides 15% of the energy intake with the labelled bean contributing >50% of the protein.

Using intrinsically labelled bean protein to assess bioavailability of amino acids in healthy adults

Tropical Metabolism Research Unit, Caribbean Institute for Health Research, University of the West Indies

Quality of Protein From the Common Bean

Bioavailability of Essential Amino Acids From the Common Bean (Phaseolus Vulgaris) in Young Healthy Jamaican Adults Consuming a Typical Meal

Measured by comparing plasma enrichment of each deuterium labelled indispensable amino acid (IAA) from the bean to plasma enrichment of the same 13C- labelled IAA from a highly digestible reference protein (Universally 13C-labelled spirulina)

Calculated based on the enrichment of free L-[ring-13C6]-phenylalanine in plasma at steady state divided by its enrichment in the meal.

mg of digestible bean IAA in 1g bean protein/ mg of the same IAA in 1g reference protein

Asha Violet Badaloo

Professor

The University of The West Indies

International Atomic Energy Agency

The model is based on the concept that if amino acids in protein become labelled with an isotopic tracer within the food matrix, their appearance in the blood gives a measure of their bioavailability following digestion and absorption of the protein; which is independent of other proteins in the food and independent of endogenous body proteins and gut bacterial proteins. Amino acids in the common bean were labelled with deuterium, by adding a bolus dose of deuterium oxide (2H2O) to the irrigation water. Then a dual tracer technique is used to measure the bioavailability of amino acids in the bean. After consuming a diet prepared with the mature bean, comparative tracer appearance in blood of the deuterium labelled amino acids from the bean and amino acids derived from a reference protein labelled within another tracer (U-13C- spirulina) gives a direct measure of bioavailability of the bean amino acids.

After 2 weeks of run-in period, subjects take 2 Omnia pills per meal (3 meals a day) for 12 weeks.

After 2 weeks of run-in period, subjects take 2 Placebo pills per meal (3 meals a day) for 12 weeks.

Overweight

Omnia

Placebo

OMNIA Efficacy on Body Fat Mass Reduction

Randomised Controlled Trial, Double-blind, to Measure Efficiency and Tolerance of a New Food Supplement OMNIA on Body Fat Mass Reduction in Overweight Subjects

Vivatech

Obex will be administered two sachets daily dissolved in a glass of water, 30 minutes before lunch and dinner during two months. Patients will be recommended to comply with a healthy lifestyle through diet and exercise.

Placebo will be administered two sachets daily dissolved in a glass of water, 30 minutes before lunch and dinner during two months. Patients will be recommended to comply with a healthy lifestyle through diet and exercise.

Obesity

After concluded the two months of treatment, patients will be follow-up during three months without consumption of Obex.

Obex

After concluded the two months of treatment, patients will be follow-up during three months without consumption of the placebo.

Universidad Autónoma de Madrid

Obex, a Nutritional Supplement, in Overweight and Obese Spanish Women

Efficacy and Safety of Obex®, a Nutritional Supplement, in Overweight or Obese Women

The primary outcome is to evaluate the effect of the treatment with OBEX on skinfold thickness of the biceps, triceps, subscapular and suprailiac as compared to placebo group at 2 months of treatment.

Waist and Hip circumferences will be measured at baseline and at the end of treatment.

The arm circumference will be measured at baseline and at the end of treatment.

Body fat (%) will be assessed at baseline and the end of treatment

The muscular mass will be measured at baseline and at the end of treatment.

The arterial BP will be evaluated at baseline and at the end of treatment.

The fasting glucose and cholesterol levels will be evaluated at baseline and at the end of treatment.

phaseolus vulgaris/obesitas

Quality of Protein From the Common Bean

OMNIA Efficacy on Body Fat Mass Reduction

Obex, a Nutritional Supplement, in Overweight and Obese Spanish Women

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