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phenanthrene/demam
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[4 cases of recurring pseudo-scarlet fever due to the use of phenanthrene alkaloids with a 6-hydroxy group (codeine and morphine)].
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Comparison of a 9-phenanthrene methanol (WR33063), a 4-quinoline methanol (WR30090), and quinine for falciparum malaria in Thailand.
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Quinine was compared with a 9-phenanthrene methanol (WR33063) and a 4-quinoline methanol (WR30090) for the treatment of 207 patients with falciparum malaria in Southeast Thailand. Quinine eradicated parasitaemia (average 70 hours) more rapidly than either WR30090 (72 hours) or WR33063 (77 hours).
Four cases of recurrent pseudo-scarlet fever caused by phenathrene alkaloids with a 6-hydroxy group (codeine and morphine).
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Four patients with a clinical picture resembling that of scarlatina are described. This clinical picture was found to be based on a delayed-type allergy for codeine and morphine. Investigation showed that the codeine or morphine allergy is essentially dependent on the hydroxyl group at the 6
Autophagic and lysosomal reactions to stress in the hepatopancreas of blue mussels.
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The aim of this investigation was to test the reactions of the hepatopancreatic digestive cells of blue mussels (Mytilus edulis and Mytilus galloprovincialis) to a variety of environmental stressors. These stressors included anoxia, hyperthermia, polycyclic aromatic hydrocarbons, copper and a
Clinical experience with halofantrine in the treatment of malaria.
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Halofantrine hydrochloride (HF) belongs to a new class of antimalarials, the phenanthrene methanols. Preliminary clinical studies suggested that an adult dose of 500 mg 6-hourly for three doses, with a weight-based regimen of 8 mg/kg 6-hourly for three doses in children, would be effective. In an
Is halofantrine still advisable in malaria attacks?
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Halofantrine is an antimalarial drug which is widely prescribed for the treatment of infections with chloroquine-resistant strains of Plasmodium falciparum. Chemically, it is a phenanthrene methanol, belonging to the aryl-amino-alcohol family. It has recently been recognized that this drug may
A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats.
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In addition to producing antinociception, opioids exert profound effects on body temperature. This study aimed at comparing antinociceptive and hyperthermic responses between two groups of μ-opioid receptor agonists: fentanyl (4-anilinopiperidine-type) and morphine (phenanthrene-type) derivatives in
The anaesthetist, opioid analgesic drugs, and serotonin toxicity: a mechanistic and clinical review.
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Most cases of serotonin toxicity are provoked by therapeutic doses of a combination of two or more serotonergic drugs, defined as drugs affecting the serotonin neurotransmitter system. Common serotonergic drugs include many antidepressants, antipsychotics, and opioid analgesics, particularly
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