Capsule containing 50 ng (5.4 nCi) [14C]-benzo[a]pyrene (BaP)

Capsule containing 50 ng (5.4 nCi) [14C]-benzo[a]pyrene (BaP) and 1250 phenanthrene

Environmental Exposure

[14C]-benzo[a]pyrene

Oral micro-dose of 50 ng (5.4 nCi) [14C]-benzo[a]pyrene plus 1250 ng phenanthrene

[14C]-benzo[a]pyrene plus phenanthrene

Oregon State University

Ultralow Dose PAH Binary Mixture Study

Plasma and urine levels of 14C-BaP and 14C-BaP metabolites measured by accelerator mass spectrometry

Determination of highest concentration of 14C-BaP in plasma

Determination of time at which plasma concentration of 14C-BaP is highest

Integration of concentration of 14C-BaP in plasma over time

Determination of constants for rate of elimination of 14C-BaP from plasma

Determination of plasma metabolites of 14C-BaP

Determination of urinary metabolites of 14C-BaP

Deidentified samples sent to Lawrence Livermore National Laboratory Deidentified data sent to Pacific Northwest National Laboratory

David Williams

Professor

National Institute of Environmental Health Sciences (NIEHS)

Lawrence Livermore National Laboratory

Pacific Northwest National Laboratory

Deidentified samples will be analyzed by AMS at Lawrence Livermore National Laboratory and the pharmacokinetics determine at Pacific Northwest National Laboratory.

Patients receive deuterated phenanthrene tetraol PO and collect urine for 6 hours after dosing.

Lung Cancer

Squamous Lung Dysplasia

Tobacco Use Disorder

deuterated phenanthrene tetraol

pharmacological study

laboratory biomarker analysis

Mayo Clinic

Roswell Park Cancer Institute

BC Cancer Agency

Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer

Correlation of [D10] Phenanthrene Metabolism With Bronchoepithelial Dysplasia and Metaplasia in Smokers at High Risk for Lung Cancer

A multiple regression analysis will be performed including explanatory variables such as lesion status, presence/absence of chronic obstructive pulmonary disease (COPD) or asbestos, duration of smoking, smoking intensity, age, and gender.

A multiple regression analysis will be performed including explanatory variables such as lesion status, presence/absence of COPD or asbestos, duration of smoking, smoking intensity, age, and gender.

University of Minnesota

National Cancer Institute (NCI)

Deuterated Phenanthrene spiked in a study cigarette

Tobacco Toxicant Exposure

Deuterated phenanthrene

Tobacco Use Research Center

Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine

Deuterated phenanthrene tetraol ([D10]PheT) assessed post dosing for smoked versus oral administration.

phenanthrene/kanker

Ultralow Dose PAH Binary Mixture Study

Deuterated Phenanthrene Tetraol in Smokers Who Are at High Risk For Lung Cancer

Determining Levels of [D10] Phenanthrene Tetraol in Smokers' Urine

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