Ivermectin has been reported to be a SARS-CoV-2 inhibitor. This activity is believed to be due to the dependence of many different RNA viruses on IMPα / β1 during infection. These reports suggested that the inhibitory activity of ivermectin nuclear transport may be effective against SARS-CoV-2, since they demonstrate that ivermectin has antiviral action against the clinical isolate of SARS-CoV-2 in vitro, with a single dose capable to control viral replication in 24-48 hours. in vitro

Severe Acute Respiratory Syndrome

Ventilation Pneumonitis

Ivermectin 5 MG/ML

Hospital Eurnekian

IVERMECTIN Aspirin Dexametasone and Enoxaparin as Treatment of Covid 19

EVALUATION of Ivermectin Aspirin Dexametasone and Enoxaparin as Treatment of covid19

Considering healing and/or reducing symptoms and severity of initial presentation

Keeping the patient(s) out of ICU, as they do not need mechanical ventilation and/or special intensive care

potential need of reducing or augmenting doses

Outcome of adverse effects to one or more drugs used in the clinical trial

Personal data will remain secret. Only clinical descriptions (age, gender, co-morbidities, evolution, outcomes will be released

Hector E Carvallo

Principal investigator

Eurnekian Public Hospital

Cancer-related Fatigue

Neutropenia, Malignant

PG2 (500 mg in 500 ml saline), 3 days via i.v. infusion per chemotherapy cycle

Astragalus polysaccharides 500 mg

500 ml saline, 3 days via i.v. infusion per chemotherapy cycle

Placebo

Epirubicin plus Cyclophosphamide every 21 days

EC Chemotherapy

E-Da Cancer Hospital

Chang Gung Memorial Hospital, Kaohsiung Branch

Chang Gung Memorial Hospital, Lakeview Branch

Chang Gung Memorial Hospital, Taipei Branch

Chang Gung Memorial Hospital, Linkou Branch

PG2 Treatment Among Stage II/III Breast Cancer Patients Receiving Adjuvant Chemotherapy

PG2 Treatment for Reduction of Chemotherapy-Induced Toxicity and Encouraging Compliance With Chemotherapy Among Stage II/III Breast Cancer Patients Receiving Adjuvant Chemotherapy

PhytoHealth Corporation

Infection, Bacterial

Antibiotic Resistant Infection

Diagnostic Self Evaluation

Meningitis, Bacterial

Nosocomial Infection

Neurosurgery dept. University Hospital

Neurosurgery department, University Hospital

Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.

analyse of different body fluids to detect the focus of infections post neurosurgical fever

Fariba Nayeri

MD, PhD, associated professor

Gynecologic cancer patients under chemotherapy

Gynecologic Cancer

Chemotherapy

Tri-Service General Hospital

A Perspective Study of Cancer-related Fatigue in Gynecologic Cancer Patients Under Chemotherapy

BFI was commonly used to evaluate the cancer-related fatigue during the clinical practice.

FACT-G7 was usually used to assess the quality of life of cancer patients during the clinical practice.

Cytokine and immune markers will be assessed from blood of cancer patients during the each chemotherapy cycle.

Cheng-Chang Chang

Chief of Division

oral Fe polysaccharide 150mg twice daily for 16 weeks

oral Fe polysaccharide 150mg twice daily for 16 weeks
Polysaccharide Iron Complex 150 mg: Oral Iron

Polysaccharide Iron Complex 150 mg

Oral placebo twice a day for 16 weeks
Placebo (for Polysaccharide Iron Complex): Sugar capsule designed to mimic Polysaccharide Iron Complex.

Placebo (for Polysaccharide Iron Complex 150 mg)

Total

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

Region of Enrollment

To determine if oral Fe (Iron) polysaccharide is superior to oral placebo in improving functional capacity as measured by change in peak VO2 by CPET (Cardiopulmonary Exercise Testing) , of a broad population of patients with HFrEF (Heart Failure with Reduced Ejection Fraction) and Fe deficiency at 16 weeks.

Change in Peak VO2 (ml/Min) (VO2 =Oxygen Consumption)

To determine the impact of oral Fe repletion on Submaximal exercise capacity as measured by 6MWT

Change From Baseline in Sub-maximal Exercise Capacity as Assessed by the 6 Minute Walk Test (6MWT)

To determine the impact of oral Fe repletion on Plasma N-terminal pro-B-type natriuretic peptide (NT-pro BNP)

Change in Plasma NT-pro BNP

To determine the impact of oral Fe repletion on Health Status: KCCQ.
KCCQ is a 23-item, self administered instrument that quantifies physical function, symptoms (frequency, severity and recent change), social function, self-efficacy and knowledge, and quality of life for patients with congestive heart failure. It is a predictive tool that tracks how patients are doing if they have weakened heart muscle due to prior heart attacks, heart valve problems, viral infections, or other causes.
The KCCQs questions are used to calculate scores in ten domains. Physical Limitation, Symptom Stability, Frequency, Burden and Total Symptom. Social Limitation, Self-Efficacy, Quality of Life, and Clinical Summary. Overall summary: a combined measure of all the above.
For each domain, the validity, reproducibility, responsiveness and interpretability have been independently established. Scores are transformed to a range of 0-100, in which higher scores reflect better health status.

Change in Health Status: Kansas City Cardiomyopathy Questionnaire (KCCQ) - Clinical Summary Score

To determine the impact of oral Fe repletion on O2 Uptake Kinetics as measured by CPET

Change From Baseline in O2 Uptake Kinetics as Assessed by Mean Response Time From CPET

Change from baseline in Ventilatory Efficiency defined by Ve/VCO2 (carbon dioxide output) as measured by CPET

Change From Baseline in Ventilatory Efficiency Defined by Ve/VCO2

Overall Study

Dr. Adrian Hernandez

Chronic Heart Failure

Sugar capsule designed to mimic Polysaccharide Iron Complex.

Placebo (for Polysaccharide Iron Complex)

Emory University School of Medicine

Johns Hopkins Hospital

Tufts Medical Center

Massachusetts General Hospital

Brigham and Women's Hospital

Mayo Clinic

Saint Louis University Hospital

Washington University School of Medicine

Duke University Medical Center

University Hospitals-Case Medical Center

Metor Health System

Cleveland Clinic Foundation

Lancaster General Hospital

Hospital of the University of Pennsylvania

Thomas Jefferson University

University of Utah Hospitals and Clinics

The University of Vermont - Fletcher Allen Health Care

Oral Iron Repletion Effects On Oxygen Uptake in Heart Failure

After the study results have been published, site-specific participant data will be shared with sites upon request. Sites are expected to follow their specific institutional policies regarding sharing results with their participants.

polysaccharide/fatigue

IVERMECTIN Aspirin Dexametasone and Enoxaparin as Treatment of Covid 19

PG2 Treatment Among Stage II/III Breast Cancer Patients Receiving Adjuvant Chemotherapy

Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients.

A Perspective Study of Cancer-related Fatigue in Gynecologic Cancer Patients Under Chemotherapy

Oral Iron Repletion Effects On Oxygen Uptake in Heart Failure

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