Patients affected by central and peripheral aneurismatic disease with maximum statin daily dose ( Atorvastatin 80 mg, Simvastatin 40 mg, Rosuvastatin 40 mg).
Patients will undergo Open Surgical Treatment of Aneurysm (Aneurysmectomy).
The investigation consist in:
taking a preoperative blood sample to evaluate the MMPs circulating levels
taking an aneurismatic vassel wall istological sample with an intraoperative biopsy to evaluate the tissue MMPs and miRNAs levels

Patients affected by central and peripheral aneurismatic disease with minimum statin daily dose.
Patients will undergo Open Surgical Treatment of Aneurysm (Aneurysmectomy).
The investigation consist in:
taking a preoperative blood sample to evaluate the MMPs circulating levels
taking an aneurismatic vassel wall istological sample with an intraoperative biopsy to evaluate the tissue MMPs and miRNAs levels

Statin

Aneurysm

Extracellular Matrix Alteration

Aneurysmectomy is a surgical procedure in which a localized, dilated, weakened section of an artery (aneurysm) is removed (resected). The artery is either replaced with a synthetic graft, as seen in an aneurysm in the chest (thoracic aneurysm), abdomen (abdominal aneurysm) or leg (femoral or popliteal aneurysm).

Open Surgical Treatment of Aneurysm (Aneurysmectomy)

University Magna Graecia of Catanzaro

Influence of Statins in Artery Aneurysms

The Influence of Statin Treatment on Aneurysmatic Disease

MMP-2, MMP-9 and NGAL will be studied in both groups. Elisa Testing will be used to analyze the blood samples and Western blot analysis will be used for the tissue samples.

Evaluation of miRNAs levels (in particular miR29b, miR-181a, miR-21, miR-150) will be studied in both groups. Stem-loop reverse-transcription PCR (RT-qPCR) method will be used for measuring individual microRNAs (miRNAs) in tissue and blood samples.

Prof. Raffaele Serra, MD, Ph.D.

Associate Professor of Vascular Surgery

University of Catanzaro

Cancer Cachexia

Ruxolitinib

Division of Hematology/Oncolgy, University Clinic of Medicine, Kantonsspital Aarau AG

Division of Hematology/Oncology, Kantonsspital Olten

Study of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases.

The RUXexia Trial: An Open-label Phase II Trial of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases.

Dual energy X-ray absorptiometry (DEXA) and bioelectrical impedance analysis (BIA)

Formula BMI = W / H2 (W=body weight in kilograms; H=body height in meters)

Reporting of adverse events according to the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 4.0

Measurement of power and speed on a stair climbing test (Stair climb speed [m/sec]=[height of 12 steps(meters)]/[time (seconds) up the 12 steps]; Stair climb power [watts]=[9.8 m/sec2]*[weight (kg)]*[height of 12 steps(meters)]/[time (seconds) up the 12 steps]).

Multiplex-assays for proinflammatory cytokines

Free oxygen radical monitor (FORM) with proper kits (FORMOX with FORT and FORD analysis kits, Callegari 1930 S.P.A., Parma, Italy).

Nathan Cantoni

Kantonsspital Aarau

Clinical Trial Unit, University Hospital Basel, Switzerland

University Hospital, Basel, Switzerland

Novartis

The study group is composed by patients with a condition that requires a procedure/surgery for oral squamous cell carcinoma treatment.
INTERVENTIONS: Collect blood, saliva and oral tissue.

Group without oral squamous cell carcinoma but with a condition that requires prosthetic procedure/surgery.
INTERVENTIONS: Collect blood, saliva and oral tissue.

This biospecimens will be retained: whole blood, exfoliated cells, saliva and formalin-fixed paraffin-embedded tissues.

proteinase/atrofi

Influence of Statins in Artery Aneurysms

Study of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases.

Human Papillomavirus on Oral Tissue, Saliva and Serum

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