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pyridoxine/kanker

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Subjects The study protocol and informed consent was approved by the Ethics Committee of the Hospital Santa Marcelina, Sao Paulo, Brazil (Process nº 09/08, CAAE nº 0016.0.270.000-08).Sixty women (figure 1) were postmenopausal selected from the outpatient Gynecology - Endocrine Hospital Santa

Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy

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Acute Lymphoblastic Leukemia (ALL) is an emerging health burden for Bangladesh. It is anticipated that about 20 million people are going to be affected annually by 2025 in countries currently on developmental transition. Good prognostic outcome of ALL relies on uninterrupted and complete course of

Plasma Vitamin and Homocysteine Levels and Thrombosis in Patients With Ph-negative MPNs

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Thirty-one new or formerly diagnosed MPN patients who consecutively visitted our outpatient clinic, as well as 40 age and sex matched healthy controls were enrolled in this study.

Phase 2 Study of Twice Weekly VELCADE and CAELYX in Patients With Ovarian Cancer Failing Platinum Containing Regimens

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OBJECTIVES: Primary - Determine whether pyridoxine can reduce the incidence of capecitabine dose modifications (dose delay and dose reductions) due to toxicity. Secondary - Determine the incidence of hand-foot syndrome (HFS). - Determine the overall toxicity. - Determine the quality of life. -

Pyridoxine in Preventing Hand-Foot Syndrome Caused by Capecitabine in Patients With Cancer

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OBJECTIVES: Primary - Compare the incidence of capecitabine-induced palmar-plantar erythrodysesthesia (hand-foot syndrome [HFS]) ≥ grade 2 in patients with cancer treated with pyridoxine hydrochloride vs placebo. Secondary - Compare the time to onset of HFS ≥ grade 2 in patients treated with these

Study of Pyridoxine for Hand-Foot Syndrome

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Although pyridoxine has been used empirically for the prevention of capecitabine associated HFS, its efficacy needs to be demonstrated in prospective controlled trials. We estimated that the HFS rate with placebo and pyridoxine would be 0.35 and 0.18, respectively, and we therefore calculated that a
OBJECTIVES: - Determine whether the prophylactic use of a topical urea/lactic acid cream can decrease the incidence/severity of capecitabine-caused palmar-plantar erythrodysesthesia in patients receiving capecitabine for breast and/or other cancer. - Evaluate the potential toxicity of this cream. -

Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Liposomal Doxorubicin for Cancer

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OBJECTIVES: Primary - Compare the efficacy of pyridoxine vs placebo in preventing palmar-plantar erythrodysesthesia (PPE) in patients receiving doxorubicin HCl liposome for recurrent ovarian, fallopian tube, or peritoneal cavity cancer, metastatic breast cancer, or advanced endometrial cancer. -

A Trial of Doxil and Multiday Vinorelbine in Patients With Metastatic Breast Cancer

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PROTOCOL SUMMARY Study design: Phase II trial of monthly Doxil® and vinorelbine on day 1 and 2 in women with metastatic breast cancer. Treatment plan: Patients will continue therapy, until they have unacceptable toxicity or disease progression. Primary endpoint: Response rate Secondary endpoints:

Homocysteine Study (HOST)

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Primary Hypothesis: The primary objective of this proposal is to test the hypothesis that administration of folate, pyridoxine (vitamin B6) and cyanocobalamin (vitamin B12) in high doses to patients with advanced chronic renal failure or end-stage renal disease and abnormally high plasma

Penicillamine, Low Copper Diet, and Radiation Therapy in Treating Patients With Glioblastoma

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OBJECTIVES: I. Determine the effect of penicillamine and copper reduction on survival and time to progression in adults with newly diagnosed glioblastoma. II. Determine the effect of penicillamine on the reduction of serum copper in these patients. III. Determine whether penicillamine reduces the
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