Participants will receive usual care from their treating neurologist

Participants will be trained via videos from a three day in-person seminar that teaches the public about the use of a therapeutic diet and lifestyle to reduce multiple sclerosis related fatigue and improve quality of life.

Clinically Isolated Syndrome

Relapsing Remitting Multiple Sclerosis

Educational videos, 4 individual support calls and monthly support group meetings conducted via an internet based audio/ video conference platform. Patients will be trained on a low lectin modified paleolithic diet; breathing meditation practice, and body weight strengthening

Therapeutic diet and lifestyle

University of Iowa

Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis

Composite scores for physical health subscales

Composite scores for mental health subscales

The number of seconds it takes to walk 25 feet

Survey asking about mood and daily activities. Change in anxiety score for the hospital anxiety and depression scale score based on the responses.

Survey asking about mood and daily activities. Change in depress score for the hospital anxiety and depression scale score based on the responses.

Terry L. Wahls

Professor

Comparison of the intervention arm to standard of care.

15 subjects will be randomly assigned to adjuvant treatment with 200mg of vitamin B6 (pyridoxine).

15 subjects will be randomly assigned to adjuvant treatment with 2mg of vitamin B12 (cobalamin).

15 subjects will be randomly assigned to adjuvant treatment with placebo.

Schizophrenia

Drug Induced Movement Disorder, Unspecified

Oxidative Stress

Adjuvant daily treatment with 200mg of pyridoxine

Pyridoxine

Adjuvant daily treatment with 2mg of cobalamin

Cobalamin

Placebo Oral Tablet

Núcleo de Pesquisa e Desenvolvimento de Medicamentos - UFC

Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

Effect of Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

10-item rating scale to assess extrapyramidal symptoms; each item is scored 0-4, yielding a total between 0 and 40.

Objective Akathisia, Subjective Awareness of Restlessness and Subjective Distress Related to Restlessness are rated on a 4-point scale from 0 - 3 and are summed yielding a total score ranging from 0 to 9. The Global Clinical Assessment of Akathisia uses a 5-point scale ranging from 0 - 4.

10-item rating scale to assess involuntary movements; items are rated on a five-point scale of severity from 0-4, yielding a total between 0 and 40.

18-item rating scale to assess changes in psychopathology; each item is scored 0-6, yielding a total between 0 and 40.

Nucleo De Pesquisa E Desenvolvimento De Medicamentos Da Universidade Federal Do Ceara

Proof of concept 12-week prospective, randomized, double-blind, controlled trial

Metadoxine 500 mg tablets by mouth every 12 hours for 6 months and metformin 500 mg tablets by mouth every 8 hours for 6 months

Placebo tablet (for Metadoxine) by mouth every 12 hours for 6 months and metformin 500 mg tablets by mouth every 8 hours for 6 months

NAFLD

Pre-diabetes

Metadoxine

Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"

Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis

Effect of Metadoxine on Oxidative Stress in Non-alcoholic Fatty Liver Disease Prediabetic Mexican Patients

ALDO TORRE DELGADILLO

Principal investigator

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Oral pyridoxine, 30- 50 mg/kg/day in one daily dose (powder form)for a period of four weeks followed by cross-over to Phenytoin arm for another four weeks

Phenytoin Oral, 5 mg/kg/day in two equally divided doses(powder form)for a period of four weeks and then cross-over to Pyridoxine arm for another four weeks

Sodium valproate oral, 10 - 15 mg/kg/day once daily powder form)for a period of four weeks and then cross-over to placebo arm for another four weeks

Placebo will consist of an inert substance (e.g., gelatin) with an appearance similar to medication in similar dosage as the study arms for a period of 4 weeks and subsequent cross-over to Sodium Valproate arm

Nodding Syndrome

Sodium Valproate

Phenytoin

Placebo

Kitgum Nodding Syndrome Treatment Center, Kitgum General Hospital

Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012

Change (Reduction) in frequency of observed head nodding or other seizure activity episodes among children with NS

pyridoxine/radang

Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis

Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

Effect of Metadoxine on Oxidative Stress in Non-alcoholic Hepatic Steatosis

Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012

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