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Quinine disposition during malaria and during induced fever.
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Quinine disposition was studied in 5 subjects before and during an experimentally induced infection with a chloroquine-resistant strain of Plasmodium falciparum and in 2 individuals before and during artificially induced fever. Plasma quinine levels were determined by both a benzene extraction
Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol.
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The effects of quinine and paracetamol on fever were studied in 21 adult patients with acute uncomplicated falciparum malaria. Quinine alone (n = 7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n = 7) or 2 h before quinine (n = 7) reduced temperature by a mean of
The effect of fever on quinine and quinidine disposition in the rat.
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The pharmacokinetics of quinine and its diastereoisomer quinidine has been investigated in normal and febrile rats. Endotoxin-induced fever in rats resulted in an increased quinine clearance (CL) (4.49 +/- 1.45 vs 1.38 +/- 0.65 L h-1 kg-1, P less than 0.001) and volume of distribution (Vd) (42.6 +/-
CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever.
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BACKGROUND
The naturally occurring alkaloid drug, quinine is commonly used for the treatment of severe malaria. Despite centuries of use, its metabolism is still not fully understood, and may play a role in the haemolytic disorders associated with the drug.
METHODS
Incubations of quinine with CYPs
A Report of Four Cases of Blackwater Fever after Quinine Treatment at Zinder National Hospital, Niger Republic.
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A study of the anti-pyretic effect of quinine, an alkaloid effective against cerebral malaria, on fever induced by bacterial endotoxin and yeast in rats.
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The effect of quinine on fever induced by lipopolysaccharide and brewer's yeast has been investigated in rats. Oral administration of 50 or 100 mg kg(-1) quinine, doses which had no effect on normothermic rats, significantly reduced lipopolysaccharide- (50 microg kg(-1), i.m.) and yeast- (2 g
Medicine: Malaria in the Mauritius-The Mosquito and Malaria-The Administration of Quinine, How and When-Anchylostomiasis in St. Lucia-An Effervescing Quinine Mixture-Scurvy and Uric Acid-Experimental Typhoid Fever-Alcohol and Immunity.
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Special Detailed Report on a Case of Enteric Fever with Remarks on the Influence of Quinine on Temperature.
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African fever, prophylactic quinine, and statistical analysis: factors in the Europe penetration of a hostile West African environment.
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A Case of Remittent Fever in a Child Aged Two Years and Nine Months, with an Idiosyncrasy Towards Quinine.
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A Preliminary Report on the Minimum Curative Dose of Quinine in the Treatment of Malarial Fever by the Intravenous Method.
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On the External Application of Oil of Turpentine as a Substitute for Quinine in Intermittent Fever, with Reports of Cases.
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The Treatment of Malarial Fever in Individuals Susceptible to Attacks of Black Water Fever by Intravenous Injection of an Antihæmolytic Quinine Solution.
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THE DIAGNOSTIC AND PROGNOSTIC VALUE OF THE LEUCOPENIA OF CACHEXIAL FEVER AND KALA-AZAR, AND ITS TREATMENT BY QUININE AND BONE MARROW.
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Blackwater Fever and Quinine.
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