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quinine/karies gigi
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Shape adaptation of quinine in cyclodextrin cavities: NMR studies.
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Complex formation between quinine and natural cyclodextrins (CD) was studied using NMR spectroscopy. The strongest association was observed for complexes of neutral quinine molecules with βCD. Association constants for monocationic quinine were one order of magnitude smaller, while dicationic
[Treatment of residual cavities in thoracoplasty by directed endocavitary injections of quinine urea salts].
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TWO CASES OF AMOEBIC ABSCESS OF LIVER: CURED BY ASPIRATION AND INJECTION OF QUININE INTO THE CAVITY WITHOUT DRAINAGE.
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Responsiveness of solitario-parabrachial relay neurons to taste and mechanical stimulation applied to the oral cavity in rats.
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A total of 311 units, responsive to natural stimulation of the oral cavity, were isolated from the rostral part of the solitary tract nucleus (NTS) of rats. Of these, 169 "taste neurons", activated by taste stimulation, and 142 mechanoreceptive units, exclusively sensitive to mechanical stimulation
The contribution of taste bud populations to bitter avoidance in mouse strains differentially sensitive to sucrose octa-acetate and quinine.
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Mice of the SWR/J (SW) strain avoid orally delivered sucrose octa-acetate (SOA), whereas the mice of the C3HeB/FeJ (C3) strain are insensitive to SOA. Mice of both strains and of a congenic strain (C3.SW) that shares more than 99% of the C3 genome, were tested in a taste-salient brief-access taste
Encapsulation of quinine by beta-cyclodextrin: excellent model for mimicking enzyme-substrate interactions.
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An inclusion complex formed by beta-cyclodextrin and quinine has been investigated in solution and in the solid state, in which the quinoline ring and the aliphatic ring locate in different hydrophobic cavities, respectively. The study on the inclusion geometry and weak interactions shows that the
Histidine at position 462 determines the low quinine sensitivity of ether-à-go-go channel superfamily member Kv 12.1.
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BACKGROUND AND PURPOSE
The ether-à-go-go (Eag) Kv superfamily comprises closely related Kv 10, Kv 11, and Kv 12 subunits. Kv 11.1 (termed hERG in humans) gained much attention, as drug-induced inhibition of these channels isNatural products for dental caries prevention.
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Selected natural compounds were evaluated for their effects on dental caries due to different strains of Streptococcus mutans bacteria. Out of 39 tested compounds, four (catechol, emetine, quinine, and flavone) showed potent inhibitory activity on different strains of S. mutans at 6.25 microg/mL or
Anterior and posterior oral cavity responsive neurons are differentially distributed among parabrachial subnuclei in rat.
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The responses of single parabrachial nucleus (PBN) neurons were recorded extracellularly to characterize their sensitivity to stimulation of individual gustatory receptor subpopulations (G neurons, n = 75) or mechanical stimulation of defined oral regions (M neurons, n = 54) then localized to
Responses of solitary tract nucleus neurons to taste and mechanical stimulations of the oral cavity in decerebrate rats.
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Physiological characteristics of 45 taste and 15 mechanoreceptive units were examined in the solitary tract nucleus (NTS) of rats decerebrated at the pre- or midcollicular level, and compared with previous findings in the intact rat. The rostro-caudal extent of the area, where taste and
Comparison of c-fos-like immunoreactivity in the brainstem following intraoral and intragastric infusions of chemical solutions in rats.
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To examine whether the activation of brainstem neurons during ingestion is due to orosensory afferents or post-ingestive factors, neuronal activation in response to intraoral and intragastric infusions of taste stimuli was compared in the area postrema (AP), nucleus tractus solitarius (NTS) and
The significance of apical K+ channels in mudpuppy feeding behavior.
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Behavioral experiments were conducted to determine the effects of known potassium channel blockers, minnow extract (a natural food substance), and other taste stimuli on feeding behavior in the mudpuppy (Necturus maculosus). Groups of 10-15 mudpuppies were presented with one or more of the following
Behavioral and neural responses to gustatory stimuli delivered non-contingently through intra-oral cannulas.
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The act of eating requires a decision by an animal to place food in its mouth. The reasons to eat are varied and include hunger as well as the food's expected reward value. Previous studies of tastant processing in the rat primary gustatory cortex (GC) have used either anesthetized or awake behaving
Sensitivity of rat cortical neurons in distinguishing taste qualities by individual and correlative activities.
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To examine the possibility that different taste qualities are represented by the correlative activity of cortical gustatory neurons, we made simultaneous recordings of neuron pairs during application of four basic tastes into the oral cavity of anesthetized rats and the following observations were
Convergence onto hamster medullary taste neurons.
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Research has shown that gustatory afferents innervating different areas of the oral cavity converge onto single neurons in the nucleus tractus solitarii (NTS). However, most studies of gustatory physiology have only stimulated the receptors on the anterior tongue. No information exists on the
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