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Facilitation of Hippocampal Kindling and Exacerbation of Kindled Seizures by Intra-CA1 Injection of Quinine: A Possible Role of Cx36 Gap Junctions.
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BACKGROUND
GABAergic interneurons in the hippocampal CA1 area are mutually communicated by gap junctions (GJs) composed of connexin36 (Cx36). We examined the role of Cx36 in CA1 in manifestation of kindled seizures and hippocampal kindling in rats.
METHODS
Quinine, as the specific blocker of Cx36,
Quinine, a blocker of neuronal cx36 channels, suppresses seizure activity in rat neocortex in vivo.
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OBJECTIVE
The selective contribution of neuronal gap junction (GJ) communication via connexin 36 (Cx36) channels to epileptogenesis and to the maintenance and propagation of seizures was investigated in both the primary focus and the mirror focus by using pharmacologic approaches with the
Differential effects of trimethylamine and quinine on seizures induced by 4-aminopyridine administration in the entorhinal cortex of vigilant rats.
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In vivo and in vitro evidence from animals suggesting that gap junctions (GJs) play a role in the spreading of epileptiform activity. We have examined the influence of the gap junction opener trimethylamine (TMA) and the connexin 36 (Cx36) gap junctional blocker, quinine, on epileptiform activity
Decreased fast ripples in the hippocampus of rats with spontaneous recurrent seizures treated with carbenoxolone and quinine.
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BACKGROUND
In models of temporal lobe epilepsy and in patients with this pathology, high frequency oscillations called fast ripples (FRs, 250-600 Hz) can be observed. FRs are considered potential biomarkers for epilepsy and, in the light of many in vitro and in silico studies, we thought that
Effects of some GABAergic agents on quinine-induced seizures in mice.
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The effects of some GABAergic agents on seizures induced by quinine were studied in mice. Muscimol, AOAA, DABA and baclofen significantly protected mice against quinine-induced convulsions. Bicuculline effectively enhanced quinine-induced convulsions, and significantly attenuated the protective
Antiepileptic effects of quinine in the pentylenetetrazole model of seizure.
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Quinine, is an anti-malarial drug that specifically blocks connexin 36 (Cx36) at gap junction channels. Quinine has suppressed ictal epileptiform activity in vitro without decreasing neuronal excitability. Thus, we considered the possible anticonvulsant effects of quinine in the pentylenetetrazole
Effect of quinine on electroshock and pentylenetetrazol-induced seizures in mice.
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1. Effect of quinine on electroshock and pentylenetetrazol (leptazol)-induced seizures was investigated in mice. 2. Quinine (0.1-100 mg/kg, ip) did not protect mice against electroshock seizure. 3. 25-100 mg/kg, ip of quinine reduced the incidence of leptazol (80-90 mg/kg, sc)-induced seizure and
[Diluted injectable quinine in the intramuscular and intrarectal route: comparative efficacity and tolerance in malaria treatment for children ].
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The intramuscular (i.m.) route is generally used for treatment of childhood falciparum malaria in outlying health care units in Togo. The purpose of this randomized therapeutic trial was to compare the efficacy and tolerance of diluted injectable quinine administered by the i.m. versus intrarectal
[A case of mefloquine-resistant Plasmodium falciparum malaria with convulsion after antimalarial treatment].
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We report a case of 40-year-old with chloroquine- and mefloquine-resistant Plasmodium falciparum. He had a single grand mal seizure 37 days following retreatment with quinine intravenously, which resulted in rapid clearance of fever and parasitemia, in addition to mefloquine. He had a long history
Risks of the consumption of beverages containing quinine.
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Although the United States Food and Drug Administration banned its use for nocturnal leg cramps due to lack of safety and efficacy, quinine is widely available in beverages including tonic water and bitter lemon. Numerous anecdotal reports suggest that products containing quinine may produce
Antiepileptic properties of Quinine: A systematic review.
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BACKGROUND
Quinine has anti-epileptic properties in animals. However, in humans this has not been systematically investigated.
OBJECTIVE
To examine the available research evidence on the effects of quinine on seizures in adults or children.
METHODS
We searched online databases for published and
Blocking of rat hippocampal Cx36 by quinine accelerates kindling epileptogenesis.
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There are abundant studies indicating that blocking gap junctions (GJs) containing connexin 36 (Cx36) inhibit seizures. However, recent evidences demonstrate proconvulsant effect of such intervention. Electrical coupling between GABAergic interneurons in CA1 region of hippocampus is mediated through
[Severe poisoning risk linked to intravenous administration of quinine].
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BACKGROUND
High concentrations of quinine, the drug of choice for severe malaria, are toxic to the cardiovascular system, producing hypotension and abnormal myocardial conduction.
METHODS
Five children, aged 14 months to 13 years, were admitted because of fever that appeared a few days after their
Hypoglycaemia in severe malaria, clinical associations and relationship to quinine dosage.
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BACKGROUND
Hypoglycaemia is an independent risk factor for death in severe malaria and a recognized adverse treatment effect of parenteral quinine. In 2006 our hospital changed quinine treatment policy from 15 mg/kg loading (plus 10 mg/kg 12-hourly) to 20 mg/kg loading (plus 10 mg/kg 8-hourly) to
High first dose quinine regimen for treating severe malaria.
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BACKGROUND
Quinine is used for treating severe malaria. There are arguments for giving an initial high dose. We examined the evidence for and against this policy.
OBJECTIVE
To assess the clinical outcomes and adverse events of a high first (loading) dose regimen of quinine compared with a uniform
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