Patients in this group will receive:
Ibuprofen
Oral
At a dosage of 30 to 40 mg/kg/day, divided into 3 or 4 doses/day, max 2400 mg/day, given with food, in the form of suspension or tablets.
Duration of therapy: 4 - 6 weeks.

Steroids:
Pednisone (for mild/moderate cases):
Oral
Single daily morning dosage of 0.05-2.0 mg/kg/day, or in 2 - 4 divided doses, max 80 mg/d.
Duration: 4 - 6 weeks, with gradual tapering to the lowest effective dose.
Methylprednisolone (for severe/acute cases):
IV
10-30 mg/kg/dose (max 1 g), over 1 hr daily for 1-5 days, followed by oral prednisone, with gradual tapering to the lowest effective dose.
The duration is variable according to the condition of the patient.

Patients in this group will receive:
Methotrexate
Oral
At a dosage of 10 to 20 mg/m2/wk (0.35 to 0.65 mg/kg/wk), max dose 25 mg/wk.
Duration of therapy: 6 - 12 weeks.

Vasculitis

Infants and children with vasculitis attending AssiutU, aged > 1 mo. - 17 yr. of both genders will be included during 2 years of study.
Besides full clinical history and thorough examination, all cases will have: CBC, CRP, ESR, Renal function tests & Albumin / creatinine ratio.
All cases will have an initial estimation as well as follow up estimation after treatment by Ibuprofen for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

Ibuprofen

Infants and children with vasculitis attending AssiutU, aged > 1 mo. - 17 yr. of both genders will be included during 2 years of study.
Besides full clinical history and thorough examination, all cases will have: CBC, CRP, ESR, Renal function tests & Albumin / creatinine ratio.
All cases will have an initial estimation as well as follow up estimation after treatment by Steroids for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

Prednisone

Infants and children with vasculitis attending AssiutU, aged > 1 mo. - 17 yr. of both genders will be included during 2 years of study.
Besides full clinical history and thorough examination, all cases will have: CBC, CRP, ESR, Renal function tests & Albumin / creatinine ratio.
All cases will have an initial estimation as well as follow up estimation after treatment by Methotrexate for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

Methotrexate

Nelson Textbook of Pediatrics Expert Consult, Chapter 161, 1-8.

American College of Rheumatology (ACR) Juvenile Idiopathic Arthritis Guideline Project Plan - June 2017

Assiut University Pediatric Hospital

The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children

The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children Attending Assiut University Hospital.

An initial estimation as well as follow up estimation after treatment for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

There is a plan to make IPD and related data dictionaries available.

RIHassan

Principal investigator

Assiut University

The aim of this work is to assess the effect of various forms of treatment of vasculitis on C3, C4, C5a & ANCA levels in blood, in infants & children.

No other parties are masked in this clinical trial.

Control group will receive placebo medication therapy

pomegranate group will receive oral pomegranate (500 mg, twice per day)

Hearing Impairment

The gel contains a mixture of glucose and maltodextrin - a complex carbohydrate - along with fat and a trace of protein.

Placebo

Pomegranate

Dalin Tzu Chi Hospital

The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis

The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis: A Prospective, Randomized, Double-blinded Clinical Trial

pure tone thresholds of 250, 500, 1000, 2000, 4000, 8000 Hz were measured.

The speech recognition threshold is the lowest hearing level at which speech can barely be recognized or understood. The SRT is defined as the lowest hearing level at which the patient correctly repeats 50% of a list of spondaic words. Examples are airplane, hot dog, outside, ice cream, and baseball. Usually a very soft level (db HL).

The SDS test tool is a single syllable word list. Each table consists of 50 words, such as, look, go. The test method is to listen to the subject at a volume higher than the SRT value of 20 to 40 dB (30 dB), so that the subject repeats the spoken word sound. Based on the percentage of correct answers, normal people can repeat 95 to 100% of the words, and 80% or less of them are bad discriminating power and affect the understanding of language. SDS is usually expressed in %.

Dalin Tzu Chi General Hospital

Patients were randomly assigned to the thalidomide group and received 100 mg of thalidomide (Pharmaceutical Co., Ltd. of Chang Zhou, China) orally four times daily at 10 p.m. for four months.

Patients were randomly assigned to the placebo group and received 100 mg of thalidomide placebo (Pharmaceutical Co., Ltd. of Chang Zhou, China) orally four times daily at 10 p.m. for four months.

Gastrointestinal Hemorrhage

Vascular Malformation

Interventions administered (dosage, 100mg; dosage form, 25mg; frequency of administration, 1 time daily at 10 p.m)

Thalidomide

Placebo administered (dosage, 100mg; dosage form, 25mg; frequency of administration, 1 time daily at 10 p.m)

Approved drug page at FDA's Drugs@FDA web site

Protocol of previous open-label, randomised, iron-controlled study of long-term effects of thalidomide for recurrent gastrointestinal bleeding due to vascular malformation

Gastroenterology department; Ren Ji Hospital

Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding

A Randomised, Double-blind, Placebo-controlled Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding

Proportion of subjects whose bleeding episode decreased from baseline by ≥ 50% at 12 months follow-up after 4-month treatment. The details are showed as follows: Reduction of bleeding episode = [(total bleeding episodes at 12 months - total bleeding episodes at a year before randomisation)/total bleeding episodes at a year before randomisation (baseline)]*100%. Rebleeding was defined based on a positive fecal occult blood test (FOBT) (monoclonal colloidal gold color technology) at any visit after treatment.

Change from baseline in bleeding episodes at 12 months

Change from baseline in bleeding duration at 12 months

Change from baseline in proportion of subjects who dependent on blood transfusions at 12 months

Change from baseline in number of blood units transfused in subjects who dependent on blood transfusions at 12 months

salicylate/atrofi

The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children

The Beneficial Effects of Pomegranate on Hearing of Patients Without Hemodialysis

Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding

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