Group 1(ASA) included 33 patients who received acetylsalicylic acid at a dose of 75 mg orally once a day in the morning.

Group 2 (STE) included 32 patients receiving tomato fruit extract (STE) (ZAAX, Sequia, Poland) at a dose of 213 mg orally once a day in the morning.

Hypertension,Essential

Obesity

Group 1(ASA) included 33 patients who received acetylsalicylic acid at a dose of 75 mg in the morning

acetylsalicylic acid

Group 2 (STE) included 32 patients receiving standardized tomato extract (STE) (ZAAX, Sequia, Poland) at a dose of 213 mg orally in the morning

Tomato Fruit Extract

Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects

Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects at High Estimated Cardiovascular Risk

The platelet inhibition after STE and ASA therapy (VerifyNow Aspirin for ASA and STE Groups and VerifyNow P2Y12 for STE Group only) The platelet reactivity measurements will be performed using the VerifyNow Tests (Accumetrics Inc., USA) method.

The reduction in office BP (measured three times in standard conditions) and in 24-hour ABPM parameters

Beata Krasinska

Principal Investigator

Subjects will take 81 mg aspirin per day for 10-14 consecutive days

Subjects will take matching placebo capsule (excipient: methylcellulose) for 10-14 consecutive days.

Episodic Migraine

Chronic Migraine

Aspirin one 81 mg capsule per day for 10-14 consecutive days

Aspirin (acetylsalicylic acid)

1 placebo capsule identical in appearance and excipient to aspirin capsule per day for 10-14 consecutive days

Placebo

The University of Washington

Aspirin Resistance in Women With Migraine

Measurement of ARU, indicative of platelet inhibition, using the VerifyNow Aspirin Assay (Accumetrics, San Diego, CA)

Aspirin acts by inhibiting production of thromboxane A2 by platelets. Thromboxane B2 is the stable product of thromboxane A2.

salicylate/infark

Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects

Aspirin Resistance in Women With Migraine

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