Patients in this group will receive:
Ibuprofen
Oral
At a dosage of 30 to 40 mg/kg/day, divided into 3 or 4 doses/day, max 2400 mg/day, given with food, in the form of suspension or tablets.
Duration of therapy: 4 - 6 weeks.

Steroids:
Pednisone (for mild/moderate cases):
Oral
Single daily morning dosage of 0.05-2.0 mg/kg/day, or in 2 - 4 divided doses, max 80 mg/d.
Duration: 4 - 6 weeks, with gradual tapering to the lowest effective dose.
Methylprednisolone (for severe/acute cases):
IV
10-30 mg/kg/dose (max 1 g), over 1 hr daily for 1-5 days, followed by oral prednisone, with gradual tapering to the lowest effective dose.
The duration is variable according to the condition of the patient.

Patients in this group will receive:
Methotrexate
Oral
At a dosage of 10 to 20 mg/m2/wk (0.35 to 0.65 mg/kg/wk), max dose 25 mg/wk.
Duration of therapy: 6 - 12 weeks.

Vasculitis

Infants and children with vasculitis attending AssiutU, aged > 1 mo. - 17 yr. of both genders will be included during 2 years of study.
Besides full clinical history and thorough examination, all cases will have: CBC, CRP, ESR, Renal function tests & Albumin / creatinine ratio.
All cases will have an initial estimation as well as follow up estimation after treatment by Ibuprofen for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

Ibuprofen

Infants and children with vasculitis attending AssiutU, aged > 1 mo. - 17 yr. of both genders will be included during 2 years of study.
Besides full clinical history and thorough examination, all cases will have: CBC, CRP, ESR, Renal function tests & Albumin / creatinine ratio.
All cases will have an initial estimation as well as follow up estimation after treatment by Steroids for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

Prednisone

Infants and children with vasculitis attending AssiutU, aged > 1 mo. - 17 yr. of both genders will be included during 2 years of study.
Besides full clinical history and thorough examination, all cases will have: CBC, CRP, ESR, Renal function tests & Albumin / creatinine ratio.
All cases will have an initial estimation as well as follow up estimation after treatment by Methotrexate for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

Methotrexate

Nelson Textbook of Pediatrics Expert Consult, Chapter 161, 1-8.

American College of Rheumatology (ACR) Juvenile Idiopathic Arthritis Guideline Project Plan - June 2017

Assiut University Pediatric Hospital

The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children

The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children Attending Assiut University Hospital.

An initial estimation as well as follow up estimation after treatment for ANCA, C3, C4 &C5a levels done, measured By ELISA technique.

There is a plan to make IPD and related data dictionaries available.

RIHassan

Principal investigator

Assiut University

The aim of this work is to assess the effect of various forms of treatment of vasculitis on C3, C4, C5a & ANCA levels in blood, in infants & children.

No other parties are masked in this clinical trial.

Subjects will take 81 mg aspirin per day for 10-14 consecutive days

Subjects will take matching placebo capsule (excipient: methylcellulose) for 10-14 consecutive days.

Episodic Migraine

Chronic Migraine

Aspirin one 81 mg capsule per day for 10-14 consecutive days

Aspirin (acetylsalicylic acid)

1 placebo capsule identical in appearance and excipient to aspirin capsule per day for 10-14 consecutive days

Placebo

The University of Washington

Aspirin Resistance in Women With Migraine

Measurement of ARU, indicative of platelet inhibition, using the VerifyNow Aspirin Assay (Accumetrics, San Diego, CA)

Aspirin acts by inhibiting production of thromboxane A2 by platelets. Thromboxane B2 is the stable product of thromboxane A2.

Jill T. Jesurum, Ph.D., Scientific Director

Swedish Medical Center

University of Washington

National Headache Foundation

Wadsworth Foundation

Accumetrics, Inc.

Bacterial Meningitis

glycerol by mouth (po) 1.5ml/kg max 25 ml/dose x 6 hourly x 8 doses
paracetamol PR 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7

Glycerol and paracetamol

paracetamol 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7 doses

Paracetamol

paracetamol po 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7 doses plus placebo suppository

po 35 mg/kg first dose, then 20 mg/kg 6 hourly x 7 doses plus placebo suppository

35 mg/kg po first dose, then 20 mg/kg 6 hourly x 7 paracetamol
1.5 ml/kg max 25 ml/dose 6 hourly x 8 doses

Paracetamol and glycerol

glycerol 1.5 ml/kg /dose 6 hourly x 8 max dose = 25ml

Glycerol

College of Medicine, Queen Elizabeth Central Hospital

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis - A Prospective, Randomized, and Double-Blind Clinical Study Using a Two-by-Two Factorial Design

salicylate/sakit kepala

The Effect of Some Drugs Used in Treatment of Vasculitis on the Complement System in Children

Aspirin Resistance in Women With Migraine

Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis

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