Buspirone is administered orally twice per day (9:00 AM and 6:00 PM) for 3 weeks. 10 mg buspirone is administered on days 1-4, then the dose is increased by 10 mg every 3 days to a maximum of 40 mg buspirone on days 10-19.

Placebo is administered orally twice per day (9:00 AM and 6:00 PM) for 3 weeks.

Buspirone

Placebo

Total

Sex: Female, Male

Region of Enrollment

Eye movements are analyzed using a MiraMetrix S2 Eyetracker. This outcome measure reports a ratio: [(number of anti-saccade errors with marijuana-related images) divided by (total number of anti-saccade errors with marijuana-related images or neutral images)]. Anti-saccade errors are when the subject fails to inhibit fixation onto the image.

Attentional Bias to Marijuana Specific Stimuli Measured Via Analysis of Eye Movements

The Perceived Stress Scale is a 10 item scale that was developed to measure the degree to which individuals appraise their life as stressful and has been widely used in health studies. The scale has a 5-point Likert response format. The total score is calculated by summing responses. The questions are general in nature and relatively content free with regard to specific population groups. The range of scores is 0-40, with 40 indicating the most stress.

Stress as Assessed by the Perceived Stress Scale

The Zung Self-Rated Anxiety Scale is a widely-used 20 item scale that is scored on a Likert-type scale of 1-4, with 15 questions concerning increasing anxiety levels and five questions concerning decreasing anxiety levels. The scale focuses on the most common general anxiety symptoms and means of coping with stressors that produce anxiety. The range of scores is 20-80:
20-44 Normal Range
45-59 Mild to Moderate Anxiety Levels
60-74 Marked to Severe Anxiety Levels
75-80 Extreme Anxiety Levels

Anxiety as Assessed by the Zung Self-Rated Anxiety Scale

With the Visual Analogue Stress Scale - Current (VASS-C), current stress level is ranked on a 0 - 10 visual analog scale, with 0 as no stress and 10 as extreme stress, cued by the question "Please rate your current stress level."

Stress as Assessed by the Visual Analogue Stress Scale-Current (VASS-C)

Overall Study

Scott D. Lane, PhD

Cannabis Use Disorder

Buspirone is an anxiolytic compound marked by modulation of both 5-HT1A and D3 receptors. Buspirone is administered orally twice per day (9:00 AM and 6:00 PM) for 3 weeks. 10 mg buspirone is administered on days 1-4, then the dose is increased by 10 mg every 3 days to a maximum of 40 mg buspirone on days 10-19.

University of Texas Health Science Center - Houston

Buspirone, Stress, and Attentional Bias to Marijuana Cues

Scott Lane

Professor

The University of Texas Health Science Center, Houston

National Institute on Drug Abuse (NIDA)

Placebo medication
Placebo: placebo capsules

Quetiapine treatment
Quetiapine: Quetiapine pharmacotherapy for cannabis dependence

Quetiapine

Ethnicity (NIH/OMB)

Race (NIH/OMB)

mood/anxiety disorder

Marijuana using days past 28 days

The median daily dollar value of marijuana used averaged over a one-week period for each of the 12 weeks as recorded by the Timeline Followback method

Marijuana Use, Daily Dollar Averaged Over 7 Days During Each of 12 Weeks of Study

The number of abstinent days per week over the 12 weeks of study as recorded by the Timeline Followback method. High Use group defined as 0-2 abstinent days per week, Medium Use Group as 3-5 abstinent days per week and Low Use Group as 6-7 abstinent days per week.

Number of Participants Stratified by Marijuana Abstinence Days Per Week

john mariani. MD

Cannabis Dependence

Quetiapine pharmacotherapy for cannabis dependence

New York State Psychiatric Institute

Quetiapine Pharmacotherapy for Cannabis Dependence

John Mariani MD

research psychiatrist

Open label treatment with quetiapine
quetiapine: Quetiapine treatment from 25 mg daily to 300 mg twice daily

serotonin/cannabis

Buspirone, Stress, and Attentional Bias to Marijuana Cues

Quetiapine Pharmacotherapy for Cannabis Dependence

Study of Quetiapine Treatment for Cannabis Dependence

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