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10 hasil
5-HTP and Creatine for Depression
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Major depressive disorder (MDD) has a lifetime prevalence of over 16%1 and is associated with reduced work productivity,2 disability,3 increased mortality,4 and increased rates of suicide attempts5 and completed suicides.6 Unfortunately, ~34% fail to respond to standard ADs (ADs).7 Environmental and
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea
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The dogma over the past 3 decades, particularly in the field of sleep medicine, has been that intermittent hypoxia (IH) is a detrimental stimulus that leads to a number of co‐morbidities including autonomic (e.g. increased sympathetic nervous system activity), cardiovascular (e.g. hypertension,
Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females
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Serotonin and creatine are processed separately in the brain, and deficits in these brain biochemicals lead to distinct clinical problems. Therefore, investigators believe that treatment with a combination therapy, which could correct both deficits, would have a synergistic effect in the treatment
Obstructive Sleep Apnea and Arousal Threshold in Patients With Post-traumatic Stress Disorder
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Obstructive sleep apnea (OSA) is a clinically relevant disease that is associated with cardiovascular, metabolic, and neurocognitive consequences. OSA is a very common disease; the Wisconsin Sleep Cohort Study found that OSA affects 2% of women and 4% of men aged 30-60. However, these data predate
Efficacy of Fluoxetine Against Seizure-induced Central Apneas
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Acute Intermittent Hypoxia and Body Weight Supported Treadmill Training for Incomplete Spinal Cord Injury Patients
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Currently, there is no "cure" for spinal cord injuries (SCI). Although the scientific understanding of central nervous system (CNS) regeneration has advanced greatly in the past twenty years, there are still many unknowns with regard to inducing successful regeneration, especially with chronic SCI.
5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females
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Serotonin and creatine are processed separately in the brain, and deficits in these brain biochemicals lead to distinct clinical problems. Therefore, investigators believe that treatment with a combination therapy, which could correct both deficits, would have a synergistic effect in the treatment
Ibuprofen vs Acetaminophen for AMS Prevention
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Acute mountain sickness (AMS) is a well-known disorder in sojourners to high altitude (>2000m) characterized by headache, nausea and tiredness, akin to hangover-like symptoms. The Lake Louise criteria for AMS was primarily developed to allow uniformity in comparing the prevalence of AMS in different
The Phenotyping and Genotyping of Taiwanese Patients With Obstructive Sleep Apnea
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Obstructive sleep apnea (OSA) is characterized with recurrent collapse of upper airway during sleep resulting in hypoxia and sleep fragmentation. Patients of OSA might have symptoms like snoring, non-restorative sleep, witnessed apnea, and excessive daytime sleepiness. Currently, polysomnography is
Pituitary Derived-Intermedin is an Estrogen-Modulated Factor for Reducing Blood Pressure
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Specific Aim:
Validation that intermedin represents an estrogen-regulated vasoactive hormone from the pituitary
Hypothesis:
Intermedin is a mediator of the vaso-regulatory effects of estrogens.
Rationale:
In the Preliminary Study, we showed that intermedin is a pituitary-derived hypotensive factor
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